Elavl2 ELAV like RNA binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Elavl2provided by RGD
Official Full Name: ELAV like RNA binding protein 2provided by RGD
Primary source: RGD:628611
See related: Ensembl:ENSRNOG00000006853 AllianceGenome:RGD:628611
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hub; Elav2
Summary: Predicted to enable RNA binding activity. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in synapse. Predicted to be part of ribonucleoprotein complex. Orthologous to human ELAVL2 (ELAV like RNA binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 109.6), Testes (RPKM 10.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 5q32

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (111076705..111202341, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (105960872..106086463, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (109499410..109651829, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Weighted gene co-expression network analysis reveals specific modules and hub genes related to neuropathic pain in dorsal root ganglions.
Title: Weighted gene co-expression network analysis reveals specific modules and hub genes related to neuropathic pain in dorsal root ganglions.
The predominant expression of REST4, HuB/C/D and nPTB in post-mitotic fiber cells, together with miR-124 expression in vertebrate lenses, was shown.
Title: HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens.
findings indicated a specific developmental pattern of expression of HuB in the postnatal cerebellum; data suggest critical roles for HuB at the very earliest stages of neuronal differentiation, such as cell cycle exit
Title: AUF1 and Hu proteins in the developing rat brain: implication in the proliferation and differentiation of neural progenitors.
Part of a family of RNa-binding proteins found in sensory neurons.
Title: Neuron-specific Hu proteins sub-cellular localization in primary sensory neurons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC337033P1 (e-PCR)
- UniSTS:273165

U29088 (e-PCR)
- UniSTS:125714

Elavl2 (e-PCR), detects polymorphism
- UniSTS:526921

Elavl4 (e-PCR), detects polymorphism
- UniSTS:143434

Elavl2 (e-PCR), detects polymorphism
- UniSTS:498265

Elavl2 (e-PCR), detects polymorphism
- UniSTS:479106

ELAVL2__7577 (e-PCR)
- UniSTS:466144

Elavl2 (e-PCR), detects polymorphism
- UniSTS:526822

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cerebellar granule cell to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cerebellar granule cell to Purkinje cell synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ELAV-like protein 2

Names: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B); ELAV like neuron-specific RNA binding protein 2; RNA binding protein HuB; embryonic lethal, abnormal vision-like 2; hu-antigen B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302217.2 → NP_001289146.1 ELAV-like protein 2

See identical proteins and their annotated locations for NP_001289146.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A1B0GWQ5, A6JRF7, G3V6U4

Related

ENSRNOP00000009034.7, ENSRNOT00000009034.8

Conserved Domains (1) summary

TIGR01661
Location:65 → 387

ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

111076705..111202341 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287239.1 → XP_063143309.1 ELAV-like protein 2 isoform X6
XM_063287238.1 → XP_063143308.1 ELAV-like protein 2 isoform X4
XM_063287232.1 → XP_063143302.1 ELAV-like protein 2 isoform X1
XM_063287235.1 → XP_063143305.1 ELAV-like protein 2 isoform X2

UniProtKB/TrEMBL

A6JRF7, G3V6U4
XM_063287231.1 → XP_063143301.1 ELAV-like protein 2 isoform X1
XM_063287241.1 → XP_063143311.1 ELAV-like protein 2 isoform X6
XM_063287237.1 → XP_063143307.1 ELAV-like protein 2 isoform X3
XM_063287228.1 → XP_063143298.1 ELAV-like protein 2 isoform X3
XM_063287229.1 → XP_063143299.1 ELAV-like protein 2 isoform X4
XM_063287230.1 → XP_063143300.1 ELAV-like protein 2 isoform X5
XM_063287227.1 → XP_063143297.1 ELAV-like protein 2 isoform X2

UniProtKB/TrEMBL

A6JRF7, G3V6U4
XM_063287226.1 → XP_063143296.1 ELAV-like protein 2 isoform X1
XM_063287240.1 → XP_063143310.1 ELAV-like protein 2 isoform X6
XM_063287244.1 → XP_063143314.1 ELAV-like protein 2 isoform X6
XM_063287236.1 → XP_063143306.1 ELAV-like protein 2 isoform X3
XM_063287233.1 → XP_063143303.1 ELAV-like protein 2 isoform X1
XM_063287234.1 → XP_063143304.1 ELAV-like protein 2 isoform X2

UniProtKB/TrEMBL

A6JRF7, G3V6U4
XM_063287242.1 → XP_063143312.1 ELAV-like protein 2 isoform X7
XM_063287243.1 → XP_063143313.1 ELAV-like protein 2 isoform X7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_173309.2: Suppressed sequence

Description

NM_173309.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.