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Pnrc1 proline-rich nuclear receptor coactivator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 286988, updated on 13-Apr-2024

Summary

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Symbol
Pnrc1provided by RGD
Full Name
proline-rich nuclear receptor coactivator 1provided by RGD
Primary source
RGD:628753
See related
Ensembl:ENSRNOG00000007793 AllianceGenome:RGD:628753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Prol2
Summary
Predicted to be active in nucleus. Orthologous to human PNRC1 (proline rich nuclear receptor coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 477.5), Spleen (RPKM 337.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pnrc1 in Genome Data Viewer
Location:
5q21
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (52443400..52489303, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (47647070..47657832, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (48501472..48504511, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene peptidase M20 domain containing 2 Neighboring gene serine and arginine rich splicing factor 12 Neighboring gene uncharacterized LOC108350948 Neighboring gene RNA guanylyltransferase and 5'-phosphatase Neighboring gene eukaryotic initiation factor 4A-I pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation of a rat bronchiolar epithelial cell cDNA library: isolation of a proline rich protein highly enriched in bronchiolar epithelial cells. Bingle CD. Biochem Biophys Res Commun, 1996 Aug 23. PMID 8780705
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
proline-rich nuclear receptor coactivator 1
Names
proline rich 2
proline-rich protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173322.2 → NP_775444.2  proline-rich nuclear receptor coactivator 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q63647
    UniProtKB/TrEMBL
    A6IIL5, R9PXT3
    Related
    ENSRNOP00000010271.6, ENSRNOT00000010271.7
    Conserved Domains (1) summary
    pfam15365
    Location:249 → 267
    PNRC; Proline-rich nuclear receptor coactivator motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    52443400..52489303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109351.2 → XP_038965279.1  proline-rich nuclear receptor coactivator 1 isoform X1

    Conserved Domains (1) summary
    pfam15365
    Location:108 → 126
    PNRC; Proline-rich nuclear receptor coactivator motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63647.2 GenPept UniProtKB/Swiss-Prot:Q63647

Gene LinkOut

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