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Zfp13 zinc finger protein 13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287095, updated on 3-Apr-2024

Summary

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Official Symbol
Zfp13provided by RGD
Official Full Name
zinc finger protein 13provided by RGD
Primary source
RGD:1304577
See related
Ensembl:ENSRNOG00000003455 AllianceGenome:RGD:1304577
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of hydrogen peroxide biosynthetic process; and positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to be located in mitochondrion. Predicted to be integral component of membrane. Orthologous to human ZNF205 (zinc finger protein 205). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 30.8), Heart (RPKM 15.8) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp13 in Genome Data Viewer
Location:
10q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13119707..13128284, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (12615455..12623615, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (12908643..12916784, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 213 Neighboring gene uncharacterized LOC120095040 Neighboring gene small nucleolar RNA SNORA2/SNORA34 family Neighboring gene zinc finger and SCAN domain containing 10 Neighboring gene matrix metallopeptidase 25 Neighboring gene uncharacterized LOC102557038

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel transcriptional repressor, Rhit, is involved in heat-inducible and age-dependent expression of Mpv17-like protein, a participant in reactive oxygen species metabolism. Iida R, et al. Mol Cell Biol, 2010 May. PMID 20231359, Free PMC Article
  2. Identification of Rhit as a novel transcriptional repressor of human Mpv17-like protein with a mitigating effect on mitochondrial dysfunction, and its transcriptional regulation by FOXD3 and GABP. Iida R, et al. Free Radic Biol Med, 2012 Apr 15. PMID 22306510
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 205

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395554.1 → NP_001382483.1  zinc finger protein 205

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6GKB8
    Related
    ENSRNOP00000093521.1, ENSRNOT00000096198.1
    Conserved Domains (3) summary
    smart00349
    Location:114 → 165
    KRAB; krueppel associated box
    COG5048
    Location:352 → 512
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:406 → 426
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    13119707..13128284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268543.1 → XP_063124613.1  zinc finger protein 205 isoform X4

    UniProtKB/TrEMBL
    D3ZT76

  2. XM_063268540.1 → XP_063124610.1  zinc finger protein 205 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GKB8

  3. XM_063268539.1 → XP_063124609.1  zinc finger protein 205 isoform X1

  4. XM_063268541.1 → XP_063124611.1  zinc finger protein 205 isoform X3

  5. XM_063268538.1 → XP_063124608.1  zinc finger protein 205 isoform X1

  6. XM_063268542.1 → XP_063124612.1  zinc finger protein 205 isoform X4

    UniProtKB/TrEMBL
    D3ZT76

  7. XM_063268544.1 → XP_063124614.1  zinc finger protein 205 isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105765.1: Suppressed sequence

    Description
    NM_001105765.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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