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Chtf18 chromosome transmission fidelity factor 18 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287146, updated on 5-Mar-2024

Summary

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Official Symbol
Chtf18provided by RGD
Official Full Name
chromosome transmission fidelity factor 18provided by RGD
Primary source
RGD:1310473
See related
Ensembl:ENSRNOG00000019174 AllianceGenome:RGD:1310473
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in positive regulation of DNA-directed DNA polymerase activity. Predicted to act upstream of or within cell development; meiotic nuclear division; and negative regulation of chromosome segregation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Ctf18 RFC-like complex. Predicted to be active in nucleus. Orthologous to human CHTF18 (chromosome transmission fidelity factor 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 38.6), Spleen (RPKM 27.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15247525..15255573, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14743006..14751044, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15090762..15098825, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene lipase maturation factor 1 Neighboring gene uncharacterized LOC120095315 Neighboring gene G protein subunit gamma 13 Neighboring gene RNA pseudouridine synthase domain containing 1 Neighboring gene mesothelin-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Germline expression of mammalian CTF18, an evolutionarily conserved protein required for germ cell proliferation in the fly and sister chromatid cohesion in yeast. Berkowitz KM, et al. Mol Hum Reprod, 2008 Mar. PMID 18250106
  2. Disruption of CHTF18 causes defective meiotic recombination in male mice. Berkowitz KM, et al. PLoS Genet, 2012. PMID 23133398, Free PMC Article
  3. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. Bermudez VP, et al. Proc Natl Acad Sci U S A, 2003 Sep 2. PMID 12930902, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA clamp loader activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to single-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within germ cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
chromosome transmission fidelity protein 18 homolog
Names
CTF18, chromosome transmission fidelity factor 18 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105773.1 → NP_001099243.1  chromosome transmission fidelity protein 18 homolog

    See identical proteins and their annotated locations for NP_001099243.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A8I6ALU6, A6HD39, D4AC99
    Related
    ENSRNOP00000089836.1, ENSRNOT00000099898.1
    Conserved Domains (2) summary
    cd00009
    Location:345 → 515
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    cl19912
    Location:485 → 552
    DNA_pol3_delta; DNA polymerase III, delta subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15247525..15255573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245936.5 → XP_006245998.1  chromosome transmission fidelity protein 18 homolog isoform X1

    UniProtKB/TrEMBL
    D4AC99
    Conserved Domains (2) summary
    cd00009
    Location:346 → 516
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    cl19912
    Location:486 → 553
    DNA_pol3_delta; DNA polymerase III, delta subunit

  2. XM_017597066.3 → XP_017452555.1  chromosome transmission fidelity protein 18 homolog isoform X2

    UniProtKB/TrEMBL
    D4AC99
    Related
    ENSRNOP00000026139.7
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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