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Ska2 spindle and kinetochore associated complex subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287598, updated on 2-May-2024

Summary

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Official Symbol
Ska2provided by RGD
Official Full Name
spindle and kinetochore associated complex subunit 2provided by RGD
Primary source
RGD:1307084
See related
Ensembl:ENSRNOG00000025981 AllianceGenome:RGD:1307084
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam33a; RGD1307084
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including chromosome segregation; mitotic cell cycle; and regulation of microtubule polymerization or depolymerization. Predicted to be located in cytoplasm. Predicted to be part of outer kinetochore. Predicted to be active in spindle microtubule. Orthologous to human SKA2 (spindle and kinetochore associated complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 112.8), Heart (RPKM 84.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q26
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (72418707..72436721)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (71921474..71939461)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (74413989..74431922)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase domain containing 1 Neighboring gene interferon induced transmembrane protein 1, pseudogene 1 Neighboring gene uncharacterized LOC120095167 Neighboring gene SMG8 nonsense mediated mRNA decay factor Neighboring gene proline rich 11 Neighboring gene microRNA 301a Neighboring gene tripartite motif-containing 37 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1E Neighboring gene uncharacterized LOC134480846

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. Hanisch A, et al. EMBO J, 2006 Nov 29. PMID 17093495, Free PMC Article
  2. The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility. Welburn JP, et al. Dev Cell, 2009 Mar. PMID 19289083, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC109093

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in attachment of mitotic spindle microtubules to kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic sister chromatid segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of microtubule polymerization or depolymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization or depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
part_of outer kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of outer kinetochore ISO
Inferred from Sequence Orthology
more info
  
part_of outer kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
spindle and kinetochore-associated protein 2
Names
family with sequence similarity 33, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009624.1 → NP_001009624.1  spindle and kinetochore-associated protein 2

    See identical proteins and their annotated locations for NP_001009624.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088264
    UniProtKB/Swiss-Prot
    Q5I0J4
    UniProtKB/TrEMBL
    A6HHS9
    Related
    ENSRNOP00000033780.3, ENSRNOT00000036098.4
    Conserved Domains (1) summary
    cl17165
    Location:5 → 120
    SKA2; Spindle and kinetochore-associated protein 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    72418707..72436721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085562.2 → XP_038941490.1  spindle and kinetochore-associated protein 2 isoform X1

    Conserved Domains (1) summary
    cl17165
    Location:2 → 57
    SKA2; Spindle and kinetochore-associated protein 2

RNA

  1. XR_010055156.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I0J4.1 GenPept UniProtKB/Swiss-Prot:Q5I0J4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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