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Pcgf2 polycomb group ring finger 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287662, updated on 5-Mar-2024

Summary

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Official Symbol
Pcgf2provided by RGD
Official Full Name
polycomb group ring finger 2provided by RGD
Primary source
RGD:1305097
See related
Ensembl:ENSRNOG00000012705 AllianceGenome:RGD:1305097
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rnf110
Summary
Predicted to enable promoter-specific chromatin binding activity. Predicted to be involved in heterochromatin assembly; histone H2A-K119 monoubiquitination; and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including cellular response to hydrogen peroxide; chordate embryonic development; and negative regulation of apoptotic signaling pathway. Predicted to be located in nuclear body and sex chromatin. Predicted to be part of PRC1 complex. Orthologous to human PCGF2 (polycomb group ring finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 30.1), Lung (RPKM 20.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pcgf2 in Genome Data Viewer
Location:
10q31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83178926..83191610, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82682563..82694563, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85631829..85642591, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095289 Neighboring gene MLLT6, PHD finger containing Neighboring gene CDGSH iron sulfur domain 3 Neighboring gene transfer RNA asparagine (anticodon GUU) 10 Neighboring gene proteasome 20S subunit beta 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The mouse Edr2 (Mph2) gene has two forms of mRNA encoding 90- and 36-kDa polypeptides. Yamaki M, et al. Gene, 2002 Apr 17. PMID 12034499
  2. BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. Taherbhoy AM, et al. Nat Commun, 2015 Jul 7. PMID 26151332
  3. PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation. Almeida M, et al. Science, 2017 Jun 9. PMID 28596365, Free PMC Article
  4. A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton. Akasaka T, et al. Development, 1996 May. PMID 8625838
  5. A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1. Negishi M, et al. PLoS One, 2010 Aug 24. PMID 20808772, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables promoter-specific chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables ubiquitin-protein transferase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic skeletal system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PRC1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of sex chromatin ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polycomb group RING finger protein 2
Names
ring finger protein 110

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105836.2 → NP_001099306.1  polycomb group RING finger protein 2

    See identical proteins and their annotated locations for NP_001099306.1

    Status: PROVISIONAL

    Source sequence(s)
    BC167059
    UniProtKB/TrEMBL
    A6HIL6, A6HIL7, B2RZ82
    Related
    ENSRNOP00000017241.4, ENSRNOT00000017241.6
    Conserved Domains (3) summary
    PHA03247
    Location:222 → 304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130 → 228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    83178926..83191610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085606.2 → XP_038941534.1  polycomb group RING finger protein 2 isoform X1

    UniProtKB/TrEMBL
    A6HIL6, A6HIL7, B2RZ82
    Conserved Domains (3) summary
    PHA03247
    Location:222 → 304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130 → 228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

  2. XM_008767971.3 → XP_008766193.1  polycomb group RING finger protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008766193.1

    UniProtKB/TrEMBL
    A6HIL6, A6HIL7, B2RZ82
    Conserved Domains (3) summary
    PHA03247
    Location:222 → 304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130 → 228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

  3. XM_008767972.3 → XP_008766194.1  polycomb group RING finger protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008766194.1

    UniProtKB/TrEMBL
    A6HIL6, A6HIL7, B2RZ82
    Conserved Domains (3) summary
    PHA03247
    Location:222 → 304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130 → 228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

  4. XM_008767973.4 → XP_008766195.1  polycomb group RING finger protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008766195.1

    UniProtKB/TrEMBL
    A6HIL6, A6HIL7, B2RZ82
    Conserved Domains (3) summary
    PHA03247
    Location:222 → 304
    PHA03247; large tegument protein UL36; Provisional
    cd16736
    Location:12 → 65
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130 → 228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
Nucleotide Protein Strain
Heading Accession and Version

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