Cavin1 caveolae associated protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cavin1provided by RGD
Official Full Name: caveolae associated protein 1provided by RGD
Primary source: RGD:1307685
See related: Ensembl:ENSRNOG00000019778 AllianceGenome:RGD:1307685
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity and rRNA primary transcript binding activity. Predicted to be involved in positive regulation of cell motility; protein secretion; and transcription, DNA-templated. Located in caveola. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 4. Orthologous to human CAVIN1 (caveolae associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 1633.3), Heart (RPKM 1291.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86384401..86398240, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (85884100..85896136, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88862513..88874495, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cavin-1 downregulation in neointimal formation promotes vascular smooth muscle cell proliferation, migration, and synchronously enhancing caveolin-1 lysosomal degradation.
Title: Downregulation of Cavin-1 Expression via Increasing Caveolin-1 Degradation Prompts the Proliferation and Migration of Vascular Smooth Muscle Cells in Balloon Injury-Induced Neointimal Hyperplasia.
The PTRF and lack of SDPR may contribute not only to the morphology of the basal plasma membrane as observed at the time of implantation, but also to the maintenance of epithelial polarity during early pregnancy.
Title: PTRF is associated with caveolin 1 at the time of receptivity: but SDPR is absent at the same time.
Data suggest that skin cells from rats with diabetes type 2 exhibit oxidative stress, heightened cell senescence, and up-regulation of Ptrf and caveolin-1 expression.
Title: Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes.
Expression of caveolar proteins cavin-1 and caveolin-1 on adipocytes from individual rats is tightly related to adipocyte cell surface area.
Title: Adipocyte size and cellular expression of caveolar proteins analyzed by confocal microscopy.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Rat207 (e-PCR), detects polymorphism
- UniSTS:226318

Ptrf (e-PCR), detects polymorphism
- UniSTS:545868

AA849865 (e-PCR)
- UniSTS:250344

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables rRNA primary transcript binding	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA primary transcript binding	ISO Inferred from Sequence Orthology more info
enables rRNA primary transcript binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of cell motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein secretion	ISO Inferred from Sequence Orthology more info
involved_in rRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in rRNA transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in termination of RNA polymerase I transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within termination of RNA polymerase I transcription	ISO Inferred from Sequence Orthology more info
involved_in termination of RNA polymerase I transcription	ISO Inferred from Sequence Orthology more info
involved_in termination of RNA polymerase I transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in transcription initiation at RNA polymerase I promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase I promoter	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation at RNA polymerase I promoter	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in caveola	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: caveolae-associated protein 1

Names: cav-p60; cavin; cavin-1; polymerase I and transcript release factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105841.1 → NP_001099311.1 caveolae-associated protein 1

See identical proteins and their annotated locations for NP_001099311.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/Swiss-Prot

P85125

UniProtKB/TrEMBL

A6HJ65

Conserved Domains (1) summary

pfam15237
Location:51 → 322

PTRF_SDPR; PTRF/SDPR family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

86384401..86398240 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085613.2 → XP_038941541.1 caveolae-associated protein 1 isoform X1

UniProtKB/TrEMBL

G3V8L9

Related

ENSRNOP00000026783.4

Conserved Domains (1) summary

pfam15237
Location:50 → 185

PTRF_SDPR; PTRF/SDPR family