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Coasy Coenzyme A synthase [ Rattus norvegicus (Norway rat) ]

Gene ID: 287711, updated on 5-Mar-2024

Summary

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Official Symbol
Coasyprovided by RGD
Official Full Name
Coenzyme A synthaseprovided by RGD
Primary source
RGD:1549767
See related
Ensembl:ENSRNOG00000019918 AllianceGenome:RGD:1549767
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dephospho-CoA kinase activity and pantetheine-phosphate adenylyltransferase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be located in mitochondrial matrix. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia. Orthologous to human COASY (Coenzyme A synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 152.5), Liver (RPKM 149.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Coasy in Genome Data Viewer
Location:
10q31
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86514850..86519130)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86014566..86018849)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88992413..88996677)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene N-acetyl-alpha-glucosaminidase Neighboring gene hydroxysteroid (17-beta) dehydrogenase 1 Neighboring gene MAX dimerization protein MLX Neighboring gene PSMC3 interacting protein Neighboring gene uncharacterized LOC134480875 Neighboring gene reticulophagy regulator family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exome sequence reveals mutations in CoA synthase as a cause of neurodegeneration with brain iron accumulation. Dusi S, et al. Am J Hum Genet, 2014 Jan 2. PMID 24360804, Free PMC Article
  2. Identification of a novel CoA synthase isoform, which is primarily expressed in the brain. Nemazanyy I, et al. Biochem Biophys Res Commun, 2006 Mar 24. PMID 16460672
  3. Molecular cloning of CoA Synthase. The missing link in CoA biosynthesis. Zhyvoloup A, et al. J Biol Chem, 2002 Jun 21. PMID 11980892
  4. Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase). Aghajanian S, et al. Biochem J, 2002 Jul 1. PMID 11994049, Free PMC Article
  5. Specific interaction between S6K1 and CoA synthase: a potential link between the mTOR/S6K pathway, CoA biosynthesis and energy metabolism. Nemazanyy I, et al. FEBS Lett, 2004 Dec 17. PMID 15589845

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94749

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables dephospho-CoA kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dephospho-CoA kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables pantetheine-phosphate adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pantetheine-phosphate adenylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within coenzyme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in coenzyme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bifunctional coenzyme A synthase
Names
CoA synthase
NP_001006955.1
XP_006247338.1
XP_038941544.1
XP_063124807.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006954.1 → NP_001006955.1  bifunctional coenzyme A synthase precursor

    See identical proteins and their annotated locations for NP_001006955.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083781
    UniProtKB/TrEMBL
    Q5XIA5
    Related
    ENSRNOP00000027061.2, ENSRNOT00000027061.4
    Conserved Domains (2) summary
    cd02164
    Location:192 → 338
    PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
    cd02022
    Location:359 → 535
    DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    86514850..86519130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247276.5 → XP_006247338.1  bifunctional coenzyme A synthase isoform X1

    See identical proteins and their annotated locations for XP_006247338.1

    UniProtKB/TrEMBL
    Q5XIA5
    Conserved Domains (2) summary
    cd02164
    Location:192 → 338
    PPAT_CoAS; phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes
    cd02022
    Location:359 → 535
    DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.

  2. XM_039085616.2 → XP_038941544.1  bifunctional coenzyme A synthase isoform X2

    Conserved Domains (2) summary
    cd02022
    Location:65 → 241
    DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.
    cl00015
    Location:1 → 44
    nt_trans; nucleotidyl transferase superfamily

  3. XM_063268737.1 → XP_063124807.1  bifunctional coenzyme A synthase isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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