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Klhl6 kelch-like family member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287974, updated on 5-Mar-2024

Summary

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Official Symbol
Klhl6provided by RGD
Official Full Name
kelch-like family member 6provided by RGD
Primary source
RGD:1307521
See related
Ensembl:ENSRNOG00000001908 AllianceGenome:RGD:1307521
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in B cell receptor signaling pathway and germinal center formation. Predicted to act upstream of or within response to bacterium. Orthologous to human KLHL6 (kelch like family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 206.0), Spleen (RPKM 153.7) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klhl6 in Genome Data Viewer
Location:
11q23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (94475262..94514653)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80970917..81010593)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (84745958..84785315)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene kelch-like family member 24 Neighboring gene transfer RNA threonine (anticodon AGU) 24 Neighboring gene EWS RNA-binding protein 5 Neighboring gene EWS RNA-binding protein 3 Neighboring gene uncharacterized LOC120095700 Neighboring gene microRNA 6323 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation. Kroll J, et al. Mol Cell Biol, 2005 Oct. PMID 16166635, Free PMC Article
  2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in germinal center formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 6
Names
kelch-like 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105867.1 → NP_001099337.1  kelch-like protein 6

    See identical proteins and their annotated locations for NP_001099337.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473999
    UniProtKB/TrEMBL
    A6JSC3, D4A1Z1
    Related
    ENSRNOP00000002617.5, ENSRNOT00000002617.7
    Conserved Domains (6) summary
    smart00612
    Location:420 → 466
    Kelch; Kelch domain
    smart00225
    Location:71 → 163
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00038
    Location:368 → 405
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:60 → 163
    BTB; BTB/POZ domain
    pfam01344
    Location:457 → 501
    Kelch_1; Kelch motif
    pfam07707
    Location:172 → 274
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    94475262..94514653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270327.1 → XP_063126397.1  kelch-like protein 6 isoform X2

  2. XM_006248594.3 → XP_006248656.1  kelch-like protein 6 isoform X1

    Conserved Domains (5) summary
    smart00612
    Location:323 → 369
    Kelch; Kelch domain
    sd00038
    Location:271 → 308
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:1 → 66
    BTB; BTB/POZ domain
    pfam01344
    Location:360 → 404
    Kelch_1; Kelch motif
    pfam07707
    Location:75 → 177
    BACK; BTB And C-terminal Kelch
Nucleotide Protein Strain
Heading Accession and Version

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