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Ccdc14 coiled-coil domain containing 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288054, updated on 13-Apr-2024

Summary

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Official Symbol
Ccdc14provided by RGD
Official Full Name
coiled-coil domain containing 14provided by RGD
Primary source
RGD:1562189
See related
Ensembl:ENSRNOG00000021469 AllianceGenome:RGD:1562189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562189
Summary
Predicted to be involved in protein localization to centrosome and substantia nigra development. Predicted to be located in centrosome. Predicted to be active in centriolar satellite. Orthologous to human CCDC14 (coiled-coil domain containing 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 31.3), Spleen (RPKM 25.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (79557267..79593128, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (66052063..66087915, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (69281000..69316897, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481010 Neighboring gene myosin light chain kinase Neighboring gene KxDL motif containing 1, pseudogene 1 Neighboring gene non-histone chromosomal protein HMG-17-like Neighboring gene uncharacterized LOC120095665 Neighboring gene rhophilin associated tail protein 1 Neighboring gene kalirin, RhoGEF kinase Neighboring gene G2/mitotic-specific cyclin-B1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. Kodani A, et al. Elife, 2015 Aug 22. PMID 26297806, Free PMC Article
  2. Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Chen S, et al. Neurochem Res, 2012 Dec. PMID 22926577
  3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in protein localization to centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in substantia nigra development ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427244.1 → NP_001414173.1  coiled-coil domain-containing protein 14

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    79557267..79593128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768771.4 → XP_008766993.1  coiled-coil domain-containing protein 14 isoform X1

    See identical proteins and their annotated locations for XP_008766993.1

    UniProtKB/TrEMBL
    A6IRI2, D3ZBB5
    Conserved Domains (1) summary
    pfam15254
    Location:2 → 758
    CCDC14; Coiled-coil domain-containing protein 14

  2. XM_039088917.2 → XP_038944845.1  coiled-coil domain-containing protein 14 isoform X1

    UniProtKB/TrEMBL
    A6IRI2, D3ZBB5
    Conserved Domains (1) summary
    pfam15254
    Location:2 → 758
    CCDC14; Coiled-coil domain-containing protein 14

  3. XM_039088916.2 → XP_038944844.1  coiled-coil domain-containing protein 14 isoform X1

    UniProtKB/TrEMBL
    A6IRI2, D3ZBB5
    Conserved Domains (1) summary
    pfam15254
    Location:2 → 758
    CCDC14; Coiled-coil domain-containing protein 14

  4. XM_039088918.2 → XP_038944846.1  coiled-coil domain-containing protein 14 isoform X2

    UniProtKB/TrEMBL
    A6IRI5
    Conserved Domains (1) summary
    pfam15254
    Location:96 → 486
    CCDC14; Coiled-coil domain-containing protein 14

  5. XM_039088919.2 → XP_038944847.1  coiled-coil domain-containing protein 14 isoform X3

    UniProtKB/TrEMBL
    A6IRI5
    Conserved Domains (1) summary
    pfam15254
    Location:96 → 497
    CCDC14; Coiled-coil domain-containing protein 14
Nucleotide Protein Strain
Heading Accession and Version

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