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Slc9c1 solute carrier family 9 member C1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288117, updated on 2-May-2024

Summary

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Official Symbol
Slc9c1provided by RGD
Official Full Name
solute carrier family 9 member C1provided by RGD
Primary source
RGD:1309075
See related
Ensembl:ENSRNOG00000022007 AllianceGenome:RGD:1309075
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gm610; Slc9a10
Summary
Predicted to enable solute:proton antiporter activity. Predicted to be involved in anion transmembrane transport; proton transmembrane transport; and sodium ion transport. Predicted to act upstream of or within flagellated sperm motility. Predicted to be located in motile cilium. Orthologous to human SLC9C1 (solute carrier family 9 member C1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 169.8) See more
Orthologs
human mouse all
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Genomic context

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See Slc9c1 in Genome Data Viewer
Location:
11q21
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (68674380..68740874, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (55211774..55278285, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (60184953..60251458, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 3 open reading frame 52 Neighboring gene germinal center-associated, signaling and motility Neighboring gene Tnf receptor associated factor 4, pseudogene 1 Neighboring gene CD200 molecule like 2 Neighboring gene uncharacterized LOC134480998

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility. Wang D, et al. Nat Cell Biol, 2003 Dec. PMID 14634667
  2. Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs. Oduru S, et al. BMC Genomics, 2003 Jun 3. PMID 12783626, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium/hydrogen exchanger 10
Names
solute carrier family 9, member 10
solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1
sperm-specific sodium proton exchanger

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008762.2 → NP_001008762.2  sodium/hydrogen exchanger 10

    See identical proteins and their annotated locations for NP_001008762.2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A0G2K938
    Related
    ENSRNOP00000074847.2, ENSRNOT00000080148.3
    Conserved Domains (3) summary
    COG0664
    Location:890 → 1077
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:893 → 1020
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cl01133
    Location:35 → 457
    Na_H_Exchanger; Sodium/hydrogen exchanger family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    68674380..68740874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088182.2 → XP_038944110.1  sodium/hydrogen exchanger 10 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K938
    Conserved Domains (2) summary
    cd00038
    Location:831 → 958
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cl01133
    Location:35 → 457
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  2. XM_017597925.3 → XP_017453414.1  sodium/hydrogen exchanger 10 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K938
    Conserved Domains (3) summary
    COG0664
    Location:890 → 1077
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:893 → 1020
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cl01133
    Location:35 → 457
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  3. XM_017597926.3 → XP_017453415.1  sodium/hydrogen exchanger 10 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K938
    Conserved Domains (3) summary
    COG0664
    Location:890 → 1077
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:893 → 1020
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cl01133
    Location:35 → 457
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  4. XM_017597927.3 → XP_017453416.1  sodium/hydrogen exchanger 10 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K938
    Conserved Domains (3) summary
    COG0664
    Location:890 → 1077
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:893 → 1020
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cl01133
    Location:35 → 457
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  5. XM_008768722.4 → XP_008766944.1  sodium/hydrogen exchanger 10 isoform X1

    See identical proteins and their annotated locations for XP_008766944.1

    UniProtKB/TrEMBL
    A0A0G2K938
    Conserved Domains (3) summary
    COG0664
    Location:890 → 1077
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:893 → 1020
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cl01133
    Location:35 → 457
    Na_H_Exchanger; Sodium/hydrogen exchanger family
Nucleotide Protein Strain
Heading Accession and Version

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