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GPX7 glutathione peroxidase 7 [ Homo sapiens (human) ]

Gene ID: 2882, updated on 4-Jan-2025

Summary

Official Symbol
GPX7provided by HGNC
Official Full Name
glutathione peroxidase 7provided by HGNC
Primary source
HGNC:HGNC:4559
See related
Ensembl:ENSG00000116157 MIM:615784; AllianceGenome:HGNC:4559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPX6; CL683; GPx-7; NPGPx; GSHPx-7
Summary
Enables catalase activity. Predicted to be involved in cellular response to oxidative stress. Located in endoplasmic reticulum. Implicated in Barrett's adenocarcinoma and Barrett's esophagus. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in placenta (RPKM 15.6), thyroid (RPKM 9.2) and 24 other tissues See more
Orthologs
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Genomic context

See GPX7 in Genome Data Viewer
Location:
1p32.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (52602371..52609051)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (52483604..52490521)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53068043..53074723)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene terminal uridylyl transferase 4 Neighboring gene uncharacterized LOC105378723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 893 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53036969-53037469 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene 7 Neighboring gene uncharacterized LOC124904178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1035 Neighboring gene shisa like 2A Neighboring gene Sharpr-MPRA regulatory region 2435 Neighboring gene Sharpr-MPRA regulatory region 753 Neighboring gene Sharpr-MPRA regulatory region 13275 Neighboring gene MPRA-validated peak230 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 897 Neighboring gene cytochrome c oxidase assembly factor 7

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with GPX7; predicted interaction to be within the endoplasmic reticulum and function as thioredoxin reductase PubMed
Tat tat HIV-1 Tat causes a greater than 50% decrease in intracellular reduced glutathione (GSH), leading to the extracellular appearance of acidic FGF-1, an effect that is partially mediated through modulation of GSH biosynthetic enzymes PubMed
tat Expression of HIV-1 Tat in HeLa cells downregulates cytoplasmic glutathione peroxidase while upregulating phospholipid hydroperoxide glutathione peroxidase, thereby deregulating intracellular oxidant/antioxidant balance and amplifying UV sensitivity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ14777

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables catalase activity PubMed 
enables glutathione peroxidase activity  
enables peroxidase activity PubMed 
enables peroxidase activity  
enables protein binding PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum lumen  
located_in extracellular region  

General protein information

Preferred Names
glutathione peroxidase 7
Names
glutathione peroxidase 6
non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase
NP_056511.2
XP_047274516.1
XP_047274520.1
XP_054192135.1
XP_054192136.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015696.5NP_056511.2  glutathione peroxidase 7 precursor

    See identical proteins and their annotated locations for NP_056511.2

    Status: VALIDATED

    Source sequence(s)
    AK027683, BI550170, BU627166
    Consensus CDS
    CCDS569.1
    UniProtKB/Swiss-Prot
    O95337, Q5T501, Q96SL4
    Related
    ENSP00000354677.4, ENST00000361314.5
    Conserved Domains (1) summary
    TIGR02540
    Location:24176
    gpx7; putative glutathione peroxidase Gpx7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    52602371..52609051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418560.1XP_047274516.1  glutathione peroxidase 7 isoform X1

  2. XM_047418564.1XP_047274520.1  glutathione peroxidase 7 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    52483604..52490521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336160.1XP_054192135.1  glutathione peroxidase 7 isoform X1

  2. XM_054336161.1XP_054192136.1  glutathione peroxidase 7 isoform X2

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