U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pigp phosphatidylinositol glycan anchor biosynthesis, class P [ Rattus norvegicus (Norway rat) ]

Gene ID: 288238, updated on 30-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Pigpprovided by RGD
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Pprovided by RGD
Primary source
RGD:1307205
See related
Ensembl:ENSRNOG00000039850 AllianceGenome:RGD:1307205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dscr5
Summary
Predicted to contribute to phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to act upstream of or within GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 55. Orthologous to human PIGP (phosphatidylinositol glycan anchor biosynthesis class P). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 265.8), Kidney (RPKM 213.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (47152601..47158766, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (33682943..33689111, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (34592128..34598253, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene holocarboxylase synthetase Neighboring gene small nuclear ribonucleoprotein F-like Neighboring gene ripply transcriptional repressor 3 Neighboring gene tetratricopeptide repeat domain 3 Neighboring gene U1 spliceosomal RNA Neighboring gene large ribosomal subunit protein uL5-like Neighboring gene VPS26 endosomal protein sorting factor C

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Compound heterozygous mutations in the gene PIGP are associated with early infantile epileptic encephalopathy. Johnstone DL, et al. Hum Mol Genet, 2017 May 1. PMID 28334793
  2. Molecular cloning and characterization of a gene expressed in mouse developing tongue, mDscr5 gene, a homolog of human DSCR5 (Down syndrome Critical Region gene 5). Choi DK, et al. Mamm Genome, 2001 May. PMID 11331941
  3. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. Watanabe R, et al. EMBO J, 2000 Aug 15. PMID 10944123, Free PMC Article
  4. Gene expression profiling of purified rat retinal ganglion cells. Farkas RH, et al. Invest Ophthalmol Vis Sci, 2004 Aug. PMID 15277470
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to phosphatidylinositol N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
phosphatidylinositol N-acetylglucosaminyltransferase subunit P
Names
Down syndrome critical region gene 5
phosphatidylinositol glycan, class P
NP_001093228.1
NP_001386191.1
XP_006248104.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099758.2 → NP_001093228.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit P

    See identical proteins and their annotated locations for NP_001093228.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    B2GUT8
    Conserved Domains (1) summary
    pfam08510
    Location:11 → 124
    PIG-P

  2. NM_001399262.1 → NP_001386191.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit P

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    B2GUT8
    Conserved Domains (1) summary
    pfam08510
    Location:11 → 124
    PIG-P

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    47152601..47158766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248042.5 → XP_006248104.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit P isoform X1

    UniProtKB/TrEMBL
    F7FA59
    Related
    ENSRNOP00000059988.2
    Conserved Domains (1) summary
    pfam08510
    Location:46 → 159
    PIG-P; PIG-P
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous