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Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [ Rattus norvegicus (Norway rat) ]

Gene ID: 288259, updated on 5-Mar-2024

Summary

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Official Symbol
Gartprovided by RGD
Official Full Name
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetaseprovided by RGD
Primary source
RGD:1308717
See related
Ensembl:ENSRNOG00000028292 AllianceGenome:RGD:1308717
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables phosphoribosylamine-glycine ligase activity; phosphoribosylformylglycinamidine cyclo-ligase activity; and phosphoribosylglycinamide formyltransferase activity. Involved in several processes, including brain development; brainstem development; and tetrahydrofolate biosynthetic process. Predicted to be active in cytosol. Orthologous to human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 234.7), Spleen (RPKM 213.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q11
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (44351841..44377086, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (30864896..30891125, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (31780477..31805728, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 50B Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene SON DNA and RNA binding protein Neighboring gene DNA replication fork stabilization factor DONSON Neighboring gene crystallin zeta like 1 Neighboring gene intersectin 1 Neighboring gene uncharacterized LOC134481057

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GART expression in rat spinal cord after injury and its role in inflammation. Zhang D, et al. Brain Res, 2014 May 20. PMID 24709117
  2. Characterization of mammalian phosphoribosylglycineamide formyltransferase from transformed cells. Daubner SC, et al. Cancer Res, 1985 Oct. PMID 4027981
  3. Purification of mammalian glycinamide ribonucleotide (GAR) synthetase. Hards RG, et al. Adv Exp Med Biol, 1986. PMID 3532702
  4. Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR. Zhang Y, et al. Biochemistry, 2002 Dec 3. PMID 12450384
  5. Developmental changes in the folate-dependent enzymes of de novo purine biosynthesis in rat brain. Domínguez J, et al. J Neurochem, 1982 Mar. PMID 7057182

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylamine-glycine ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylamine-glycine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylamine-glycine ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoribosylformylglycinamidine cyclo-ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylformylglycinamidine cyclo-ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylformylglycinamidine cyclo-ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoribosylglycinamide formyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoribosylglycinamide formyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 'de novo' AMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' IMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in 'de novo' XMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in adenine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brainstem development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cerebral cortex development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glycine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to inorganic substance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to organic substance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
trifunctional purine biosynthetic protein adenosine-3
NP_001011899.2
XP_017453430.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011899.2 → NP_001011899.2  trifunctional purine biosynthetic protein adenosine-3

    See identical proteins and their annotated locations for NP_001011899.2

    Status: PROVISIONAL

    Source sequence(s)
    CH473989
    UniProtKB/TrEMBL
    A6JLG8, G3V918
    Related
    ENSRNOP00000033253.4, ENSRNOT00000032162.5
    Conserved Domains (7) summary
    cd02196
    Location:469 → 767
    PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
    cd08645
    Location:809 → 991
    FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
    PRK00885
    Location:4 → 427
    PRK00885; phosphoribosylamine--glycine ligase; Provisional
    PRK05385
    Location:435 → 766
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
    pfam01071
    Location:105 → 298
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    pfam02843
    Location:334 → 424
    GARS_C; Phosphoribosylglycinamide synthetase, C domain
    pfam02844
    Location:4 → 104
    GARS_N; Phosphoribosylglycinamide synthetase, N domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    44351841..44377086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597941.3 → XP_017453430.1  trifunctional purine biosynthetic protein adenosine-3 isoform X1

    UniProtKB/TrEMBL
    A6JLG8, G3V918
    Conserved Domains (7) summary
    cd02196
    Location:469 → 767
    PurM; PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis. ...
    cd08645
    Location:809 → 991
    FMT_core_GART; Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART)
    PRK00885
    Location:4 → 427
    PRK00885; phosphoribosylamine--glycine ligase; Provisional
    PRK05385
    Location:435 → 766
    PRK05385; phosphoribosylaminoimidazole synthetase; Provisional
    pfam01071
    Location:105 → 298
    GARS_A; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    pfam02843
    Location:334 → 424
    GARS_C; Phosphoribosylglycinamide synthetase, C domain
    pfam02844
    Location:4 → 104
    GARS_N; Phosphoribosylglycinamide synthetase, N domain
Nucleotide Protein Strain
Heading Accession and Version

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