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N6amt1 N-6 adenine-specific DNA methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288309, updated on 2-May-2024

Summary

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Official Symbol
N6amt1provided by RGD
Official Full Name
N-6 adenine-specific DNA methyltransferase 1provided by RGD
Primary source
RGD:1311843
See related
Ensembl:ENSRNOG00000001603 AllianceGenome:RGD:1311843
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hemk2; RGD1311843
Summary
Predicted to enable S-adenosyl-L-methionine binding activity and S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in arsonoacetate metabolic process; macromolecule methylation; and toxin metabolic process. Predicted to act upstream of or within positive regulation of cell growth. Predicted to be located in nucleus. Predicted to be part of eRF1 methyltransferase complex. Orthologous to human N6AMT1 (N-6 adenine-specific DNA methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 95.7), Heart (RPKM 65.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See N6amt1 in Genome Data Viewer
Location:
11q11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (40071017..40083463)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (26584750..26597790)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (27004335..27016690)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit beta 3, pseudogene 2 Neighboring gene serine and arginine rich splicing factor 3, pseudogene 7 Neighboring gene listerin E3 ubiquitin protein ligase 1 Neighboring gene RWD domain containing 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and primarily function study of two novel putative N5-glutamine methyltransferase (Hemk) splice variants from mouse stem cells. Nie DS, et al. Mol Biol Rep, 2009 Nov. PMID 19116772
  2. KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. Metzger E, et al. Nat Struct Mol Biol, 2019 May. PMID 31061526
  3. N(6)-Methyladenine DNA Modification in the Human Genome. Xiao CL, et al. Mol Cell, 2018 Jul 19. PMID 30017583
  4. Substrate Specificity of the HEMK2 Protein Glutamine Methyltransferase and Identification of Novel Substrates. Kusevic D, et al. J Biol Chem, 2016 Mar 18. PMID 26797129, Free PMC Article
  5. Interactive Effects of N6AMT1 and As3MT in Arsenic Biomethylation. Zhang H, et al. Toxicol Sci, 2015 Aug. PMID 25997655, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
  
enables S-adenosylmethionine-dependent methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arsenite methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H4K12 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-glutamine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables site-specific DNA-methyltransferase (adenine-specific) activity ISO
Inferred from Sequence Orthology
more info
  
enables site-specific DNA-methyltransferase (adenine-specific) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in arsonoacetate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in toxin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of eRF1 methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
methyltransferase N6AMT1
Names
HemK methyltransferase family member 2
N-6 adenine-specific DNA methyltransferase 1 (putative)
NP_001178521.1
XP_038944153.1
XP_038944154.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191592.1 → NP_001178521.1  methyltransferase N6AMT1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A8I6AGJ1, D4ACA2
    Related
    ENSRNOP00000002182.5, ENSRNOT00000002182.8
    Conserved Domains (2) summary
    COG2890
    Location:20 → 190
    HemK; Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]
    cl17173
    Location:21 → 213
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    40071017..40083463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088225.2 → XP_038944153.1  methyltransferase N6AMT1 isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:10 → 148
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_039088226.2 → XP_038944154.1  methyltransferase N6AMT1 isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:10 → 148
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein Strain
Heading Accession and Version

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