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Zfp12 zinc finger protein 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288486, updated on 13-Apr-2024

Summary

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Symbol
Zfp12provided by RGD
Full Name
zinc finger protein 12provided by RGD
Primary source
RGD:1564396
See related
AllianceGenome:RGD:1564396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564396
Summary
Predicted to enable sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to be located in centrosome and nucleoplasm. Orthologous to human ZNF12 (zinc finger protein 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 50.0), Thymus (RPKM 39.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp12 in Genome Data Viewer
Location:
12p11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (16430546..16446063, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (11316971..11330498, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (13370504..13384034, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 853 Neighboring gene zinc finger protein 316 Neighboring gene speedy/RINGO cell cycle regulator family member E4 Neighboring gene speedy/RINGO cell cycle regulator family member E4, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ZNF325, a novel human zinc finger protein with a RBaK-like RB-binding domain, inhibits AP-1- and SRE-mediated transcriptional activity. Zhao Y, et al. Biochem Biophys Res Commun, 2006 Aug 11. PMID 16806083
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • AC126572.1

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427192.1 → NP_001414121.1  zinc finger protein 12

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6K1M0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    16430546..16446063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_221917.11 → XP_221917.5  zinc finger protein 12 isoform X1

    See identical proteins and their annotated locations for XP_221917.5

    UniProtKB/TrEMBL
    A6K1M1
    Conserved Domains (6) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:300 → 676
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:320 → 340
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:402 → 424
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:8 → 47
    KRAB; KRAB box
    pfam13465
    Location:472 → 497
    zf-H2C2_2; Zinc-finger double domain

  2. XM_063271141.1 → XP_063127211.1  zinc finger protein 12 isoform X2

  3. XM_063271140.1 → XP_063127210.1  zinc finger protein 12 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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