Ksr2 kinase suppressor of ras 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ksr2provided by RGD
Official Full Name: kinase suppressor of ras 2provided by RGD
Primary source: RGD:1562674
See related: Ensembl:ENSRNOG00000028630 AllianceGenome:RGD:1562674
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562674
Summary: Predicted to enable MAP-kinase scaffold activity; mitogen-activated protein kinase kinase binding activity; and protein kinase activity. Predicted to be involved in Ras protein signal transduction; calcium-mediated signaling; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be active in cytosol and plasma membrane. Orthologous to human KSR2 (kinase suppressor of ras 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 24.3), Liver (RPKM 18.4) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (44462579..44848555, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (38802796..39187809, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (44531376..44911835, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF406370 (e-PCR)
- UniSTS:248349

D12Got93 (e-PCR)
- UniSTS:112177

BF403270 (e-PCR)
- UniSTS:246371

RH133186 (e-PCR)
- UniSTS:216469

D12Rat87 (e-PCR), detects polymorphism
- UniSTS:226481

BE120958 (e-PCR)
- UniSTS:247485

RH144202 (e-PCR)
- UniSTS:233448

d12rat31 (e-PCR)
- UniSTS:120826

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP-kinase scaffold activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinase suppressor of Ras 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

44462579..44848555 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249485.5 → XP_006249547.1 kinase suppressor of Ras 2 isoform X2

See identical proteins and their annotated locations for XP_006249547.1

UniProtKB/TrEMBL

A0A8I5Y9T2, F1LY04

Related

ENSRNOP00000077881.1

Conserved Domains (4) summary

cd00029
Location:413 → 455

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd14153
Location:663 → 932

PK_KSR2; Pseudokinase domain of Kinase Suppressor of Ras 2

pfam07714
Location:664 → 926

Pkinase_Tyr; Protein tyrosine kinase

pfam13543
Location:24 → 152

KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
XM_017598534.3 → XP_017454023.1 kinase suppressor of Ras 2 isoform X1

UniProtKB/TrEMBL

A0A8I6G920, F1LY04