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Nanos3 nanos C2HC-type zinc finger 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 288909, updated on 2-May-2024

Summary

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Official Symbol
Nanos3provided by RGD
Official Full Name
nanos C2HC-type zinc finger 3provided by RGD
Primary source
RGD:1306672
See related
Ensembl:ENSRNOG00000031593 AllianceGenome:RGD:1306672
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in oogenesis; regulation of cell cycle; and regulation of translation. Predicted to act upstream of or within negative regulation of apoptotic signaling pathway; regulation of translation; and spermatogenesis. Predicted to be located in P-body; cytoplasmic stress granule; and nucleus. Predicted to be active in perinuclear region of cytoplasm. Orthologous to human NANOS3 (nanos C2HC-type zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 5.3), Uterus (RPKM 5.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nanos3 in Genome Data Viewer
Location:
19q11
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40889531..40893699)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23978465..23988933)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25284907..25288680, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene microRNA 181c Neighboring gene microRNA 181d Neighboring gene break repair meiotic recombinase recruitment factor 1 Neighboring gene coiled-coil and C2 domain containing 1A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population. Lolicato F, et al. Dev Biol, 2008 Jan 15. PMID 18089289
  2. Conserved role of nanos proteins in germ cell development. Tsuda M, et al. Science, 2003 Aug 29. PMID 12947200
  3. Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. Bhandari D, et al. Genes Dev, 2014 Apr 15. PMID 24736845, Free PMC Article
  4. NANOS3 function in human germ cell development. Julaton VT, et al. Hum Mol Genet, 2011 Jun 1. PMID 21421998, Free PMC Article
  5. Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Suzuki H, et al. Dev Biol, 2008 Jun 1. PMID 18436203

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in germ cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in oogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within oogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nanos homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105945.1 → NP_001099415.1  nanos homolog 3

    See identical proteins and their annotated locations for NP_001099415.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    A6IYA5, D4A138
    Related
    ENSRNOP00000045882.3, ENSRNOT00000050214.4
    Conserved Domains (1) summary
    pfam05741
    Location:57 → 109
    zf-nanos; Nanos RNA binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    40889531..40893699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255235.5 → XP_006255297.1  nanos homolog 3 isoform X1

    Conserved Domains (1) summary
    pfam05741
    Location:57 → 109
    zf-nanos; Nanos RNA binding domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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