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Lrrn2 leucine rich repeat neuronal 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289020, updated on 3-Apr-2024

Summary

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Official Symbol
Lrrn2provided by RGD
Official Full Name
leucine rich repeat neuronal 2provided by RGD
Primary source
RGD:1305482
See related
Ensembl:ENSRNOG00000009691 AllianceGenome:RGD:1305482
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human LRRN2 (leucine rich repeat neuronal 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 81.7), Adrenal (RPKM 14.0) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lrrn2 in Genome Data Viewer
Location:
13q13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (46874048..46934544)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (44321944..44382454)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (49660356..49730275)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352532 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene MDM4 regulator of p53 Neighboring gene transfer RNA lysine (anticodon UUU) 7 Neighboring gene transfer RNA lysine (anticodon UUU) 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat neuronal protein 2
Names
leucine rich repeat protein 2, neuronal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177368.1 → NP_001170839.1  leucine-rich repeat neuronal protein 2 precursor

    See identical proteins and their annotated locations for NP_001170839.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6IC64, D3ZAV8
    Related
    ENSRNOP00000097330.1, ENSRNOT00000106270.1
    Conserved Domains (7) summary
    cd00116
    Location:46 → 288
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam07679
    Location:430 → 514
    I-set; Immunoglobulin I-set domain
    sd00031
    Location:337 → 360
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:95 → 118
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:117 → 177
    LRR_8; Leucine rich repeat
    cl11960
    Location:438 → 514
    Ig; Immunoglobulin domain
    cl15307
    Location:369 → 412
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    46874048..46934544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272072.1 → XP_063128142.1  leucine-rich repeat neuronal protein 2 isoform X1

    UniProtKB/TrEMBL
    A6IC64, D3ZAV8
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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