Creg1 cellular repressor of E1A-stimulated genes 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Creg1provided by RGD
Official Full Name: cellular repressor of E1A-stimulated genes 1provided by RGD
Primary source: RGD:1306804
See related: Ensembl:ENSRNOG00000003291 AllianceGenome:RGD:1306804
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Creg
Summary: Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be part of transcription regulator complex. Predicted to be active in extracellular space. Orthologous to human CREG1 (cellular repressor of E1A stimulated genes 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 504.6), Spleen (RPKM 329.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q23

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (80552779..80565272)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (78019814..78032310)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (83972186..83984675)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CREG improves cardiac function by regulating cardiomyocytes' autophagy in diabetic myocardial infarction rats.
Title: CREG improves cardiac function by regulating cardiomyocytes' autophagy in diabetic myocardial infarction rats.
Recombinant Cellular Repressor of E1A-Stimulated Genes Protects against Renal Fibrosis in Dahl Salt-Sensitive Rats.
Title: Recombinant Cellular Repressor of E1A-Stimulated Genes Protects against Renal Fibrosis in Dahl Salt-Sensitive Rats.
CREG protected retinal cells against apoptosis by inhibiting P38/MAPK and JNK/MAPK signaling pathways and activating the PI3K-AKT signaling pathway.
Title: Antiapoptotic role of the cellular repressor of E1A-stimulated genes (CREG) in retinal photoreceptor cells in a rat model of light-induced retinal injury.
CREG is a novel mediator of vascular remodeling in response to Ang II.
Title: Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II.
The results of this study indicate that CREG acts as a novel and potent survival factor in mesenchymal stem cells.
Title: Overexpression of cellular repressor of E1A-stimulated genes inhibits TNF-α-induced apoptosis via NF-κB in mesenchymal stem cells.
This study indicates that CREG is a novel and potent survival factor for mesenchymal stem cells.
Title: Overexpressing cellular repressor of E1A-stimulated genes protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt.
CREG was found to inhibit cardiac cell growth as a novel regulator of ERK1/2 and might participate in the development of cardiac hypertrophy under pressure overload
Title: CREG, a new regulator of ERK1/2 in cardiac hypertrophy.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lysosomal lumen acidification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein CREG1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105966.1 → NP_001099436.1 protein CREG1 precursor

See identical proteins and their annotated locations for NP_001099436.1

Status: PROVISIONAL

Source sequence(s)

CH473958

UniProtKB/TrEMBL

B2GUX7, F7FH64

Related

ENSRNOP00000004394.4, ENSRNOT00000004394.7

Conserved Domains (1) summary

pfam13883
Location:50 → 216

Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

80552779..80565272

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008769625.4 → XP_008767847.2 protein CREG1 isoform X1

UniProtKB/TrEMBL

B2GUX7, F7FH64

Conserved Domains (1) summary

pfam13883
Location:50 → 216

Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase