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Kif21b kinesin family member 21B [ Rattus norvegicus (Norway rat) ]

Gene ID: 289397, updated on 2-May-2024

Summary

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Official Symbol
Kif21bprovided by RGD
Official Full Name
kinesin family member 21Bprovided by RGD
Primary source
RGD:1306206
See related
Ensembl:ENSRNOG00000008471 AllianceGenome:RGD:1306206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be located in several cellular components, including cytoplasmic vesicle; dendrite; and growth cone. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Orthologous to human KIF21B (kinesin family member 21B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 64.7), Spleen (RPKM 63.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q13
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (50127842..50177822)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (47576129..47626112)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52976505..53026750)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel subunit alpha1 S Neighboring gene achaete-scute family bHLH transcription factor 5 Neighboring gene uncharacterized LOC134481564 Neighboring gene maestro heat-like repeat family member 3 Neighboring gene mitochondrial ribosomal protein L42 like 1 Neighboring gene uncharacterized LOC120096257 Neighboring gene innate immunity activator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B. Ghiretti AE, et al. Neuron, 2016 Nov 23. PMID 27817978, Free PMC Article
  2. Three novel mutations in KIF21A highlight the importance of the third coiled-coil stalk domain in the etiology of CFEOM1. Chan WM, et al. BMC Genet, 2007 May 18. PMID 17511870, Free PMC Article
  3. Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1). Yamada K, et al. Nat Genet, 2003 Dec. PMID 14595441
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIF21B is a molecular regulator of activity-dependent trafficking and microtubule dynamicity in dendrites.
    Title: Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC189181

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within corpus callosum development ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde dendritic transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic endosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF21B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415800.1 → NP_001402729.1  kinesin-like protein KIF21B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    Related
    ENSRNOP00000094546.1, ENSRNOT00000105337.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    50127842..50177822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249856.5 → XP_006249918.1  kinesin-like protein KIF21B isoform X5

    UniProtKB/TrEMBL
    A0A0G2K7Q9, A0A8I6G960
    Related
    ENSRNOP00000074306.2
    Conserved Domains (8) summary
    smart00129
    Location:9 → 378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:1304 → 1613
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:1303 → 1611
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:7 → 372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam12474
    Location:657 → 791
    PKK; Polo kinase kinase
    pfam16034
    Location:675 → 803
    JAKMIP_CC3; JAKMIP CC3 domain
    sd00039
    Location:1310 → 1344
    7WD40; WD40 repeat [structural motif]
    cl09111
    Location:961 → 1097
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  2. XM_006249857.5 → XP_006249919.1  kinesin-like protein KIF21B isoform X6

    UniProtKB/TrEMBL
    A0A8I6AJU2
    Related
    ENSRNOP00000082225.1
    Conserved Domains (8) summary
    smart00129
    Location:9 → 378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:1303 → 1612
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:1302 → 1610
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:7 → 372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam12474
    Location:656 → 790
    PKK; Polo kinase kinase
    pfam16034
    Location:674 → 802
    JAKMIP_CC3; JAKMIP CC3 domain
    sd00039
    Location:1309 → 1343
    7WD40; WD40 repeat [structural motif]
    cl09111
    Location:960 → 1096
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  3. XM_063272196.1 → XP_063128266.1  kinesin-like protein KIF21B isoform X1

  4. XM_006249854.5 → XP_006249916.1  kinesin-like protein KIF21B isoform X3

    UniProtKB/TrEMBL
    A0A8I6AJU2
    Conserved Domains (8) summary
    smart00129
    Location:9 → 378
    KISc; Kinesin motor, catalytic domain. ATPase
    COG2319
    Location:1291 → 1599
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:1290 → 1598
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cd01372
    Location:7 → 372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    pfam12474
    Location:657 → 791
    PKK; Polo kinase kinase
    pfam16034
    Location:675 → 803
    JAKMIP_CC3; JAKMIP CC3 domain
    sd00039
    Location:1297 → 1331
    7WD40; WD40 repeat [structural motif]
    cl09111
    Location:961 → 1097
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

  5. XM_063272197.1 → XP_063128267.1  kinesin-like protein KIF21B isoform X2

    UniProtKB/Swiss-Prot
    F1M5N7

  6. XM_063272198.1 → XP_063128268.1  kinesin-like protein KIF21B isoform X4

  7. XM_039090608.2 → XP_038946536.1  kinesin-like protein KIF21B isoform X7

    UniProtKB/TrEMBL
    A0A8I6AJU2
    Conserved Domains (3) summary
    COG1196
    Location:381 → 1083
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:7 → 372
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
    cd22262
    Location:926 → 1007
    Rcc_KIF21B; regulatory coiled-coil domain found in kinesin-like protein KIF21B

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001105990.2: Suppressed sequence

    Description
    NM_001105990.2: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1M5N7.2 GenPept UniProtKB/Swiss-Prot:F1M5N7

Gene LinkOut

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