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Nuak2 NUAK family kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289419, updated on 5-Mar-2024

Summary

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Official Symbol
Nuak2provided by RGD
Official Full Name
NUAK family kinase 2provided by RGD
Primary source
RGD:1359167
See related
Ensembl:ENSRNOG00000000034 AllianceGenome:RGD:1359167
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Snark; UV126; 1200013b22rik
Summary
Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in cellular response to glucose starvation and protein phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 251.3), Adrenal (RPKM 38.5) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (46305744..46322755)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43753454..43770604)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (49092306..49109055)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene BLACAT1 overlapping LEMD1 locus Neighboring gene microRNA 135b Neighboring gene LEM domain containing 1 Neighboring gene kelch domain containing 8A Neighboring gene uncharacterized LOC120096185 Neighboring gene transmembrane and coiled-coil domain family 2 Neighboring gene dual serine/threonine and tyrosine protein kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of SNARK activity in response to cellular stresses. Lefebvre DL, et al. Biochim Biophys Acta, 2005 Jun 20. PMID 15893879
  2. Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. Suzuki A, et al. Biochem Biophys Res Commun, 2003 Nov 7. PMID 14575707
  3. Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK. Lefebvre DL, et al. Biochem J, 2001 Apr 15. PMID 11284715, Free PMC Article
  4. Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness. Legembre P, et al. J Biol Chem, 2004 Nov 5. PMID 15345718
  5. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. Humbert N, et al. EMBO J, 2010 Jan 20. PMID 19927127, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC93817

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to glucose starvation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of hippo signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of hippo signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NUAK family SNF1-like kinase 2
Names
NUAK family, SNF1-like kinase, 2
SNF1/AMP kinase-related kinase
SNF1/AMP-activated protein kinase
NP_001007618.1
XP_038946542.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007617.1 → NP_001007618.1  NUAK family SNF1-like kinase 2

    See identical proteins and their annotated locations for NP_001007618.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081899
    UniProtKB/Swiss-Prot
    Q66HE5
    UniProtKB/TrEMBL
    A0A8I6AQK6, A6IC48
    Related
    ENSRNOP00000000039.2, ENSRNOT00000000039.4
    Conserved Domains (2) summary
    smart00220
    Location:57 → 307
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:53 → 307
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    46305744..46322755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090614.2 → XP_038946542.1  NUAK family SNF1-like kinase 2 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:53 → 307
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HE5.1 GenPept UniProtKB/Swiss-Prot:Q66HE5

Gene LinkOut

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