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Klb klotho beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 289625, updated on 5-Mar-2024

Summary

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Symbol
Klbprovided by RGD
Full Name
klotho betaprovided by RGD
Primary source
RGD:1308227
See related
Ensembl:ENSRNOG00000002834 AllianceGenome:RGD:1308227
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Klb-ps1; RGD1308227; AABR07015003.1
Summary
Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Predicted to act upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Orthologous to human KLB (klotho beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 112.1), Adrenal (RPKM 29.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klb in Genome Data Viewer
Location:
14p11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (43253963..43304532, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (42899050..42950788, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (44529523..44614093, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P2 like 3 Neighboring gene lipoic acid synthetase Neighboring gene uncharacterized LOC134481848 Neighboring gene ribosomal protein L9 Neighboring gene 40S ribosomal protein S13 pseudogene Neighboring gene ribosomal protein L32 like 5 Neighboring gene small nucleolar RNA SNORA77 Neighboring gene replication factor C subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Retinitis Pigmentosa: over-expression of anti-ageing protein Klotho in degenerating photoreceptors. Farinelli P, et al. J Neurochem, 2013 Dec. PMID 23796581
  2. Different roles of N- and C- termini in the functional activity of FGF21. Micanovic R, et al. J Cell Physiol, 2009 May. PMID 19117008
  3. Liver-specific activities of FGF19 require Klotho beta. Lin BC, et al. J Biol Chem, 2007 Sep 14. PMID 17627937
  4. C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. Wu X, et al. J Biol Chem, 2008 Nov 28. PMID 18829467, Free PMC Article
  5. betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Suzuki M, et al. Mol Endocrinol, 2008 Apr. PMID 18187602, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
  
enables fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-klotho
Names
klotho beta, pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    43253963..43304532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092743.2 → XP_038948671.1  beta-klotho

    UniProtKB/TrEMBL
    D3Z8T6
    Related
    ENSRNOP00000003811.7
    Conserved Domains (1) summary
    cl23725
    Location:77 → 506
    Glyco_hydro; Glycosyl hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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