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Polm DNA polymerase mu [ Rattus norvegicus (Norway rat) ]

Gene ID: 289757, updated on 5-Mar-2024

Summary

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Official Symbol
Polmprovided by RGD
Official Full Name
DNA polymerase muprovided by RGD
Primary source
RGD:1308247
See related
Ensembl:ENSRNOG00000013647 AllianceGenome:RGD:1308247
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in double-strand break repair via nonhomologous end joining. Predicted to act upstream of or within B cell differentiation and somatic hypermutation of immunoglobulin genes. Predicted to be active in nucleus. Orthologous to human POLM (DNA polymerase mu). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 44.6), Lung (RPKM 31.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Polm in Genome Data Viewer
Location:
14q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84921039..84930649, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (80707075..80716677, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (86069378..86079327, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096651 Neighboring gene phosphoglycerate mutase 2 Neighboring gene AE binding protein 1 Neighboring gene DNA polymerase delta 2, accessory subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Polymerase mu is up-regulated during the T cell-dependent immune response and its deficiency alters developmental dynamics of spleen centroblasts. Lucas D, et al. Eur J Immunol, 2005 May. PMID 15789338
  2. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Lieber MR. Annu Rev Biochem, 2010. PMID 20192759, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in double-strand break repair via nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-directed DNA/RNA polymerase mu
Names
DNA-directed DNA polymerase mu
polymerase (DNA directed), mu
polymerase (DNA) mu
NP_001011912.1
XP_006251273.1
XP_006251274.1
XP_006251275.1
XP_006251276.1
XP_038947670.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011912.1 → NP_001011912.1  DNA-directed DNA/RNA polymerase mu

    See identical proteins and their annotated locations for NP_001011912.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081868
    UniProtKB/TrEMBL
    Q66HH0
    Conserved Domains (2) summary
    cd00141
    Location:156 → 493
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    cl00038
    Location:27 → 123
    BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    84921039..84930649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091742.2 → XP_038947670.1  DNA-directed DNA/RNA polymerase mu isoform X5

    Conserved Domains (2) summary
    cd00141
    Location:85 → 426
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    cl00038
    Location:1 → 52
    BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains

  2. XM_006251211.5 → XP_006251273.1  DNA-directed DNA/RNA polymerase mu isoform X1

    Conserved Domains (2) summary
    cd00141
    Location:176 → 517
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00483
    Location:172 → 518
    POLXc; DNA polymerase X family

  3. XM_006251213.5 → XP_006251275.1  DNA-directed DNA/RNA polymerase mu isoform X3

    Conserved Domains (3) summary
    cd00141
    Location:156 → 497
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00483
    Location:152 → 498
    POLXc; DNA polymerase X family
    cd00027
    Location:30 → 109
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

  4. XM_006251212.5 → XP_006251274.1  DNA-directed DNA/RNA polymerase mu isoform X2

    UniProtKB/TrEMBL
    F7F6Z7
    Related
    ENSRNOP00000018320.4
    Conserved Domains (2) summary
    cd00141
    Location:176 → 513
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00483
    Location:172 → 514
    POLXc; DNA polymerase X family

  5. XM_006251214.4 → XP_006251276.1  DNA-directed DNA/RNA polymerase mu isoform X4

    Conserved Domains (2) summary
    cd00141
    Location:94 → 435
    NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
    smart00483
    Location:90 → 436
    POLXc; DNA polymerase X family
Nucleotide Protein Strain
Heading Accession and Version

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