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Upp1 uridine phosphorylase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289801, updated on 13-Apr-2024

Summary

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Official Symbol
Upp1provided by RGD
Official Full Name
uridine phosphorylase 1provided by RGD
Primary source
RGD:1305566
See related
Ensembl:ENSRNOG00000004972 AllianceGenome:RGD:1305566
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and pentosyltransferase activity. Involved in cellular response to glucose starvation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Biomarker of middle cerebral artery infarction. Orthologous to human UPP1 (uridine phosphorylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 123.5), Heart (RPKM 80.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Upp1 in Genome Data Viewer
Location:
14q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (88023155..88043036)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (83809495..83829299)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (89314234..89334060)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene HUS1 checkpoint clamp component Neighboring gene similar to human chromosome 7 open reading frame 57 Neighboring gene Sad1 and UNC84 domain containing 3 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 48 Neighboring gene ATP binding cassette subfamily A member 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Active site conformational dynamics in human uridine phosphorylase 1. Roosild TP, et al. PLoS One, 2010 Sep 14. PMID 20856879, Free PMC Article
  2. Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy. Roosild TP, et al. BMC Struct Biol, 2009 Mar 16. PMID 19291308, Free PMC Article
  3. Uridine protects cortical neurons from glucose deprivation-induced death: possible role of uridine phosphorylase. Choi JW, et al. J Neurotrauma, 2008 Jun. PMID 18457515
  4. Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene. Cao D, et al. J Biol Chem, 2005 Jun 3. PMID 15772079
  5. Purification, cloning, and expression of murine uridine phosphorylase. Watanabe S, et al. J Biol Chem, 1995 May 19. PMID 7744869

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124655

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables deoxyuridine phosphorylase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables thymidine phosphorylase activity ISO
Inferred from Sequence Orthology
more info
  
enables thymidine phosphorylase activity ISO
Inferred from Sequence Orthology
more info
  
enables uridine phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uridine phosphorylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in UMP salvage ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucose starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in dCMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in dTMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dTMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dUMP catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pyrimidine nucleotide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in uridine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in uridine catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within uridine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
uridine phosphorylase 1
NP_001025196.1
XP_006251545.1
XP_006251546.1
XP_006251547.1
XP_006251549.1
XP_038947688.1
XP_038947690.1
XP_038947691.1
XP_038947692.1
XP_063129045.1
XP_063129046.1
XP_063129047.1
XP_063129048.1
XP_063129049.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030025.2 → NP_001025196.1  uridine phosphorylase 1

    See identical proteins and their annotated locations for NP_001025196.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    Q499V1
    Conserved Domains (1) summary
    cd17763
    Location:33 → 307
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    88023155..88043036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251484.5 → XP_006251546.1  uridine phosphorylase 1 isoform X1

    See identical proteins and their annotated locations for XP_006251546.1

    UniProtKB/TrEMBL
    Q499V1
    Conserved Domains (1) summary
    cd17763
    Location:33 → 307
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  2. XM_039091760.2 → XP_038947688.1  uridine phosphorylase 1 isoform X1

    UniProtKB/TrEMBL
    Q499V1
    Conserved Domains (1) summary
    cd17763
    Location:33 → 307
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  3. XM_006251483.4 → XP_006251545.1  uridine phosphorylase 1 isoform X1

    See identical proteins and their annotated locations for XP_006251545.1

    UniProtKB/TrEMBL
    Q499V1
    Conserved Domains (1) summary
    cd17763
    Location:33 → 307
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  4. XM_063272978.1 → XP_063129048.1  uridine phosphorylase 1 isoform X2

    UniProtKB/TrEMBL
    F7F0D5

  5. XM_063272977.1 → XP_063129047.1  uridine phosphorylase 1 isoform X2

    UniProtKB/TrEMBL
    F7F0D5

  6. XM_039091762.2 → XP_038947690.1  uridine phosphorylase 1 isoform X1

    UniProtKB/TrEMBL
    Q499V1
    Conserved Domains (1) summary
    cd17763
    Location:33 → 307
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  7. XM_039091764.2 → XP_038947692.1  uridine phosphorylase 1 isoform X1

    UniProtKB/TrEMBL
    Q499V1
    Conserved Domains (1) summary
    cd17763
    Location:33 → 307
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  8. XM_006251485.5 → XP_006251547.1  uridine phosphorylase 1 isoform X1

    See identical proteins and their annotated locations for XP_006251547.1

    UniProtKB/TrEMBL
    Q499V1
    Conserved Domains (1) summary
    cd17763
    Location:33 → 307
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  9. XM_006251487.4 → XP_006251549.1  uridine phosphorylase 1 isoform X2

    UniProtKB/TrEMBL
    F7F0D5
    Related
    ENSRNOP00000006765.5
    Conserved Domains (1) summary
    cd17763
    Location:32 → 306
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  10. XM_039091763.2 → XP_038947691.1  uridine phosphorylase 1 isoform X1

    UniProtKB/TrEMBL
    Q499V1
    Conserved Domains (1) summary
    cd17763
    Location:33 → 307
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  11. XM_063272975.1 → XP_063129045.1  uridine phosphorylase 1 isoform X1

    UniProtKB/TrEMBL
    Q499V1

  12. XM_063272979.1 → XP_063129049.1  uridine phosphorylase 1 isoform X2

    UniProtKB/TrEMBL
    F7F0D5

  13. XM_063272976.1 → XP_063129046.1  uridine phosphorylase 1 isoform X1

    UniProtKB/TrEMBL
    Q499V1
Nucleotide Protein Strain
Heading Accession and Version

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