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Psmc6 proteasome 26S subunit, ATPase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289990, updated on 11-Apr-2024

Summary

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Official Symbol
Psmc6provided by RGD
Official Full Name
proteasome 26S subunit, ATPase 6provided by RGD
Primary source
RGD:1308825
See related
Ensembl:ENSRNOG00000007203 AllianceGenome:RGD:1308825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and proteasome-activating activity. Involved in positive regulation of inclusion body assembly. Located in inclusion body. Part of cytosolic proteasome complex. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 356.7), Liver (RPKM 356.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15p14
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (21022314..21043785)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (18542585..18564057)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (19667453..19688916)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10-like 6 Neighboring gene G protein-coupled receptor 137C Neighboring gene REST corepressor 2 like 2 Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene farnesyl diphosphate synthase pseudogene Neighboring gene serine/threonine/tyrosine interacting protein Neighboring gene glucosamine-phosphate N-acetyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones. Rousseau E, et al. J Biol Chem, 2009 Jan 16. PMID 18986984, Free PMC Article
  2. The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis. Yi H, et al. J Biol Chem, 2007 Nov 30. PMID 17911097
  3. Subcellular localization, stoichiometry, and protein levels of 26 S proteasome subunits in yeast. Russell SJ, et al. J Biol Chem, 1999 Jul 30. PMID 10419517
  4. Purification and characterization of 26S proteasomes from human and mouse spermatozoa. Tipler CP, et al. Mol Hum Reprod, 1997 Dec. PMID 9464850
  5. Mapping the murine cardiac 26S proteasome complexes. Gomes AV, et al. Circ Res, 2006 Aug 18. PMID 16857966

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables proteasome-activating activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of inclusion body assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of cytosolic proteasome complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in inclusion body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome accessory complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome regulatory subunit 10B
Names
26S protease regulatory subunit 10B
proteasome (prosome, macropain) 26S subunit, ATPase, 6
proteasome (prosome, macropain) 26S subunit, ATPase, 6-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100509.3 → NP_001093979.1  26S proteasome regulatory subunit 10B

    See identical proteins and their annotated locations for NP_001093979.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6KDZ6, G3V6W6, Q32PW9
    Related
    ENSRNOP00000009649.4, ENSRNOT00000009649.6
    Conserved Domains (1) summary
    COG1222
    Location:18 → 401
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    21022314..21043785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093096.2 → XP_038949024.1  26S proteasome regulatory subunit 10B isoform X1

    Conserved Domains (1) summary
    COG1222
    Location:1 → 286
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version

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