Fermt2 FERM domain containing kindlin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fermt2provided by RGD
Official Full Name: FERM domain containing kindlin 2provided by RGD
Primary source: RGD:1311799
See related: Ensembl:ENSRNOG00000009102 AllianceGenome:RGD:1311799
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Plekhc1
Summary: Predicted to enable several functions, including actin filament binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and positive regulation of cellular component biogenesis. Predicted to act upstream of or within cell adhesion and protein localization to cell junction. Predicted to be located in several cellular components, including adherens junction; nucleoplasm; and stress fiber. Predicted to be active in focal adhesion. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human FERMT2 (FERM domain containing kindlin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 599.0), Muscle (RPKM 431.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p14

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (21162603..21257995, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (18682927..18751959, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (19807806..19876557, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study demonstrated that kindlin-2 plays a critical role in VSMC proliferation, migration and intimal hyperplasia via Wnt signaling. Therefore, blocking the activity of kindlin-2 represents a novel therapeutic strategy for vascular injury.
Title: Kindlin-2 siRNA inhibits vascular smooth muscle cell proliferation, migration and intimal hyperplasia via Wnt signaling.
Data suggest that kindlin-2 (Kind2/Fermt2) interacts with actin alpha 2 (Actn2) and integrin beta 1 (Itgb1) and co-localizes to cardiac sarcomere at Z-disc; knockdown of Kind2 leads to dissociation of Actn2 and Itgb1.
Title: Kindlin-2 interacts with α-actinin-2 and β1 integrin to maintain the integrity of the Z-disc in cardiac muscles.

Submit: New GeneRIF Correction

General gene information

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Markers

Plekhc1 (e-PCR), detects polymorphism
- UniSTS:498247

AI179101 (e-PCR)
- UniSTS:250491

AA960555 (e-PCR)
- UniSTS:160380

RH134534 (e-PCR)
- UniSTS:217814

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables type I transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adherens junction maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in integrin activation	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in limb development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to cell junction	ISO Inferred from Sequence Orthology more info
involved_in protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fermitin family homolog 2

Names: fermitin family member 2; pleckstrin homology domain containing, family C (with FERM domain) member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011915.1 → NP_001011915.1 fermitin family homolog 2

See identical proteins and their annotated locations for NP_001011915.1

Status: PROVISIONAL

Source sequence(s)

BC083876

UniProtKB/TrEMBL

A0A8I5ZZ14, Q5XI19

Related

ENSRNOP00000083293.1, ENSRNOT00000114951.1

Conserved Domains (5) summary

cd01237
Location:373 → 497

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

cd17181
Location:17 → 96

FERM_F0_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in kindlin-2 (KIND2)

cd17184
Location:97 → 277

FERM_F1_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-2 (KIND2)

pfam00373
Location:484 → 573

FERM_M; FERM central domain

cl17171
Location:567 → 658

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

21162603..21257995 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274090.1 → XP_063130160.1 fermitin family homolog 2 isoform X7
XM_063274086.1 → XP_063130156.1 fermitin family homolog 2 isoform X4
XM_063274085.1 → XP_063130155.1 fermitin family homolog 2 isoform X3
XM_063274084.1 → XP_063130154.1 fermitin family homolog 2 isoform X1
XM_039093097.2 → XP_038949025.1 fermitin family homolog 2 isoform X10

UniProtKB/TrEMBL

A0A8I5ZZ14, Q5XI19

Conserved Domains (5) summary

cd01237
Location:373 → 497

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

cd17181
Location:17 → 96

FERM_F0_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in kindlin-2 (KIND2)

cd17184
Location:97 → 277

FERM_F1_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-2 (KIND2)

pfam00373
Location:484 → 573

FERM_M; FERM central domain

cl17171
Location:567 → 658

PH-like; Pleckstrin homology-like domain
XM_063274092.1 → XP_063130162.1 fermitin family homolog 2 isoform X9
XM_063274088.1 → XP_063130158.1 fermitin family homolog 2 isoform X6

UniProtKB/TrEMBL

A0A0G2JWC7
XM_063274091.1 → XP_063130161.1 fermitin family homolog 2 isoform X8

UniProtKB/TrEMBL

F7ERM0
XM_063274087.1 → XP_063130157.1 fermitin family homolog 2 isoform X5

UniProtKB/TrEMBL

A0A8I6G699
XM_006251756.5 → XP_006251818.1 fermitin family homolog 2 isoform X2

See identical proteins and their annotated locations for XP_006251818.1

UniProtKB/TrEMBL

A0A8I5ZZ14

Conserved Domains (4) summary

cd01237
Location:384 → 508

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

pfam00169
Location:392 → 487

PH; PH domain

pfam00373
Location:520 → 599

FERM_M; FERM central domain

cl17171
Location:593 → 684

PH-like; Pleckstrin homology-like domain
XM_006251760.4 → XP_006251822.1 fermitin family homolog 2 isoform X9

UniProtKB/TrEMBL

A0A8I5ZZ14

Conserved Domains (5) summary

cd01237
Location:373 → 497

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

cd17181
Location:17 → 96

FERM_F0_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in kindlin-2 (KIND2)

cd17184
Location:97 → 277

FERM_F1_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-2 (KIND2)

pfam00373
Location:484 → 580

FERM_M; FERM central domain

cl17171
Location:574 → 665

PH-like; Pleckstrin homology-like domain
XM_006251759.4 → XP_006251821.1 fermitin family homolog 2 isoform X8

UniProtKB/TrEMBL

A0A8I5ZZ14, F7ERM0

Related

ENSRNOP00000012400.6

Conserved Domains (4) summary

cd01237
Location:384 → 508

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

pfam00169
Location:392 → 487

PH; PH domain

pfam00373
Location:520 → 584

FERM_M; FERM central domain

cl17171
Location:578 → 669

PH-like; Pleckstrin homology-like domain
XM_006251757.4 → XP_006251819.1 fermitin family homolog 2 isoform X5

UniProtKB/TrEMBL

A0A8I5ZZ14, A0A8I6G699

Related

ENSRNOP00000080201.1

Conserved Domains (4) summary

cd01237
Location:384 → 508

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

pfam00169
Location:392 → 487

PH; PH domain

pfam00373
Location:520 → 591

FERM_M; FERM central domain

cl17171
Location:585 → 676

PH-like; Pleckstrin homology-like domain
XM_006251755.4 → XP_006251817.1 fermitin family homolog 2 isoform X2

See identical proteins and their annotated locations for XP_006251817.1

UniProtKB/TrEMBL

A0A8I5ZZ14

Conserved Domains (4) summary

cd01237
Location:384 → 508

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

pfam00169
Location:392 → 487

PH; PH domain

pfam00373
Location:520 → 599

FERM_M; FERM central domain

cl17171
Location:593 → 684

PH-like; Pleckstrin homology-like domain