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Dlgap5 DLG associated protein 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289997, updated on 5-Mar-2024

Summary

Official Symbol
Dlgap5provided by RGD
Official Full Name
DLG associated protein 5provided by RGD
Primary source
RGD:1311247
See related
Ensembl:ENSRNOG00000010721 AllianceGenome:RGD:1311247
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dlg7
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Predicted to be located in centriolar satellite; cytosol; and mitochondrion. Predicted to be active in cytoplasm; nucleus; and spindle pole centrosome. Orthologous to human DLGAP5 (DLG associated protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 108.2), Spleen (RPKM 93.9) and 8 other tissues See more
Orthologs
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Genomic context

Location:
15p14
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (23113678..23144281, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (20633964..20664569, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (24167484..24199417, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene tumor protein, translationally-controlled 1 pseudogene 8 Neighboring gene galectin 3 Neighboring gene uncharacterized LOC120096955 Neighboring gene F-box protein 34

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in centrosome localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in kinetochore assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signaling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle pole centrosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
disks large-associated protein 5
Names
discs large homolog associated protein 5
discs, large homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135802.1NP_001129274.1  disks large-associated protein 5

    See identical proteins and their annotated locations for NP_001129274.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162031
    UniProtKB/TrEMBL
    A0A8I6ANY5, B1WC75
    Related
    ENSRNOP00000015553.5, ENSRNOT00000015553.6
    Conserved Domains (1) summary
    pfam03359
    Location:411580
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    23113678..23144281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274094.1XP_063130164.1  disks large-associated protein 5 isoform X1