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Rcbtb2 RCC1 and BTB domain containing protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290363, updated on 2-May-2024

Summary

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Official Symbol
Rcbtb2provided by RGD
Official Full Name
RCC1 and BTB domain containing protein 2provided by RGD
Primary source
RGD:735048
See related
Ensembl:ENSRNOG00000015054 AllianceGenome:RGD:735048
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Chc1l
Summary
Predicted to be located in acrosomal vesicle. Predicted to be active in cytoplasm. Orthologous to human RCBTB2 (RCC1 and BTB domain containing protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 233.9), Spleen (RPKM 120.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rcbtb2 in Genome Data Viewer
Location:
15q11
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (54729367..54774004)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (48319809..48364441)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (55029388..55074728)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L40, pseudogene 2 Neighboring gene uncharacterized LOC134482149 Neighboring gene uncharacterized LOC120097036 Neighboring gene uncharacterized LOC134482150 Neighboring gene RB transcriptional corepressor 1 Neighboring gene lysophosphatidic acid receptor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mouse RC/BTB2, a member of the RCC1 superfamily, localizes to spermatid acrosomal vesicles. Wang J, et al. PLoS One, 2012. PMID 22768142, Free PMC Article
  2. cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor. Devilder MC, et al. Genomics, 1998 Nov 15. PMID 9806834
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC72635

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within digestive tract development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lymph node development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spleen development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RCC1 and BTB domain-containing protein 2
Names
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
regulator of chromosome condensation and BTB domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199084.1 → NP_954515.1  RCC1 and BTB domain-containing protein 2

    See identical proteins and their annotated locations for NP_954515.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061766
    UniProtKB/Swiss-Prot
    Q6P798
    UniProtKB/TrEMBL
    A0A8L2R3I1, A6HTQ0
    Related
    ENSRNOP00000020836.4, ENSRNOT00000020836.7
    Conserved Domains (3) summary
    COG5184
    Location:107 → 387
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18354
    Location:374 → 490
    BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    cd18529
    Location:487 → 551
    BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    54729367..54774004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274145.1 → XP_063130215.1  RCC1 and BTB domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6P798
    UniProtKB/TrEMBL
    A6HTQ0

  2. XM_039093171.2 → XP_038949099.1  RCC1 and BTB domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2R3I1
    Conserved Domains (3) summary
    COG5184
    Location:83 → 363
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18354
    Location:350 → 466
    BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    cd18529
    Location:463 → 527
    BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

  3. XM_063274146.1 → XP_063130216.1  RCC1 and BTB domain-containing protein 2 isoform X2

  4. XM_063274147.1 → XP_063130217.1  RCC1 and BTB domain-containing protein 2 isoform X2

  5. XM_008770845.4 → XP_008769067.1  RCC1 and BTB domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008769067.1

    UniProtKB/Swiss-Prot
    Q6P798
    UniProtKB/TrEMBL
    A0A8L2R3I1, A6HTQ0
    Conserved Domains (3) summary
    COG5184
    Location:107 → 387
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18354
    Location:374 → 490
    BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    cd18529
    Location:487 → 551
    BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

  6. XM_063274148.1 → XP_063130218.1  RCC1 and BTB domain-containing protein 2 isoform X2

  7. XM_008770858.4 → XP_008769080.1  RCC1 and BTB domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_008769080.1

    UniProtKB/TrEMBL
    A0A8L2R3I1
    Conserved Domains (3) summary
    COG5184
    Location:83 → 363
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18354
    Location:350 → 466
    BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    cd18529
    Location:463 → 527
    BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

  8. XM_039093165.2 → XP_038949093.1  RCC1 and BTB domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6P798
    UniProtKB/TrEMBL
    A0A8L2R3I1, A6HTQ0
    Conserved Domains (3) summary
    COG5184
    Location:107 → 387
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18354
    Location:374 → 490
    BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    cd18529
    Location:487 → 551
    BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

  9. XM_008770846.4 → XP_008769068.1  RCC1 and BTB domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008769068.1

    UniProtKB/Swiss-Prot
    Q6P798
    UniProtKB/TrEMBL
    A0A8L2R3I1, A6HTQ0
    Conserved Domains (3) summary
    COG5184
    Location:107 → 387
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18354
    Location:374 → 490
    BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    cd18529
    Location:487 → 551
    BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

  10. XM_039093172.2 → XP_038949100.1  RCC1 and BTB domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2R3I1
    Conserved Domains (3) summary
    COG5184
    Location:83 → 363
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18354
    Location:350 → 466
    BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    cd18529
    Location:463 → 527
    BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

  11. XM_063274150.1 → XP_063130220.1  RCC1 and BTB domain-containing protein 2 isoform X2

  12. XM_063274144.1 → XP_063130214.1  RCC1 and BTB domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6P798
    UniProtKB/TrEMBL
    A6HTQ0

  13. XM_008770861.4 → XP_008769083.1  RCC1 and BTB domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_008769083.1

    UniProtKB/TrEMBL
    A0A8L2R3I1
    Conserved Domains (3) summary
    COG5184
    Location:83 → 363
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18354
    Location:350 → 466
    BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    cd18529
    Location:463 → 527
    BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

  14. XM_008770860.4 → XP_008769082.1  RCC1 and BTB domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_008769082.1

    UniProtKB/TrEMBL
    A0A8L2R3I1
    Conserved Domains (3) summary
    COG5184
    Location:83 → 363
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18354
    Location:350 → 466
    BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    cd18529
    Location:463 → 527
    BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

  15. XM_039093167.2 → XP_038949095.1  RCC1 and BTB domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6P798
    UniProtKB/TrEMBL
    A0A8L2R3I1, A6HTQ0
    Conserved Domains (3) summary
    COG5184
    Location:107 → 387
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18354
    Location:374 → 490
    BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    cd18529
    Location:487 → 551
    BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)

  16. XM_063274149.1 → XP_063130219.1  RCC1 and BTB domain-containing protein 2 isoform X2

  17. XM_039093164.2 → XP_038949092.1  RCC1 and BTB domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6P798
    UniProtKB/TrEMBL
    A0A8L2R3I1, A6HTQ0
    Conserved Domains (3) summary
    COG5184
    Location:107 → 387
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd18354
    Location:374 → 490
    BTB_POZ_RCBTB2_CHC1L; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
    cd18529
    Location:487 → 551
    BACK_RCBTB2; BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P798.1 GenPept UniProtKB/Swiss-Prot:Q6P798

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