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Anxa11 annexin A11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290527, updated on 11-Apr-2024

Summary

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Official Symbol
Anxa11provided by RGD
Official Full Name
annexin A11provided by RGD
Primary source
RGD:1309911
See related
Ensembl:ENSRNOG00000010984 AllianceGenome:RGD:1309911
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including S100 protein binding activity; calcium-dependent protein binding activity; and phospholipid binding activity. Predicted to be involved in cytokinetic process; phagocytosis; and response to calcium ion. Predicted to be located in several cellular components, including cytoplasmic vesicle; midbody; and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 23. Orthologous to human ANXA11 (annexin A11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 444.2), Kidney (RPKM 350.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16p16
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (1419627..1464590)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (1412373..1457814)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (3867193..3912043, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated like 1 Neighboring gene dCTP pyrophosphatase 1, pseudogene 2 Neighboring gene placenta associated 9 Neighboring gene uncharacterized LOC134482312

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment. Lillebostad PAG, et al. Biomolecules, 2020 Apr 24. PMID 32344647, Free PMC Article
  2. Structural and functional characterization of recombinant mouse annexin A11: influence of calcium binding. Lecona E, et al. Biochem J, 2003 Jul 15. PMID 12689336, Free PMC Article
  3. Translocation of annexin XI to neutrophil subcellular organelles. Sjölin C, et al. Biochim Biophys Acta, 1997 May 22. PMID 9188810
  4. The 56K autoantigen is identical to human annexin XI. Misaki Y, et al. J Biol Chem, 1994 Feb 11. PMID 7508441
  5. Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis. Tomas A, et al. J Cell Biol, 2004 Jun 21. PMID 15197175, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment.
    Title: Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables S100 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylethanolamine binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cytokinetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytokinetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in azurophil granule ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in specific granule ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
annexin A11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011918.1 → NP_001011918.1  annexin A11

    See identical proteins and their annotated locations for NP_001011918.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083812
    UniProtKB/TrEMBL
    A6KMI0, Q5XI77
    Related
    ENSRNOP00000014940.5, ENSRNOT00000014941.7
    Conserved Domains (1) summary
    pfam00191
    Location:202 → 267
    Annexin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    1419627..1464590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094245.2 → XP_038950173.1  annexin A11 isoform X2

    Conserved Domains (1) summary
    pfam00191
    Location:202 → 267
    Annexin

  2. XM_017600010.3 → XP_017455499.1  annexin A11 isoform X1

    UniProtKB/TrEMBL
    A6KMI0, Q5XI77
    Conserved Domains (1) summary
    pfam00191
    Location:202 → 267
    Annexin
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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