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Haus8 HAUS augmin-like complex, subunit 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290626, updated on 5-Mar-2024

Summary

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Official Symbol
Haus8provided by RGD
Official Full Name
HAUS augmin-like complex, subunit 8provided by RGD
Primary source
RGD:1311565
See related
Ensembl:ENSRNOG00000052038 AllianceGenome:RGD:1311565
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ny-sar-48; RGD1311565
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in centrosome cycle and spindle assembly. Predicted to be located in mitotic spindle microtubule. Predicted to be part of HAUS complex. Predicted to be active in centrosome; cytoplasm; and nuclear microtubule. Orthologous to human HAUS8 (HAUS augmin like complex subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 100.9), Spleen (RPKM 95.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Haus8 in Genome Data Viewer
Location:
16p14
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17964813..17979313, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17930819..17945254, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19654785..19669221, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482464 Neighboring gene zinc finger protein 878 Neighboring gene zinc finger protein 709 Neighboring gene myosin IXb Neighboring gene unconventional SNARE in the ER 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. HAUS, the 8-subunit human Augmin complex, regulates centrosome and spindle integrity. Lawo S, et al. Curr Biol, 2009 May 26. PMID 19427217
  2. The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells. Uehara R, et al. Proc Natl Acad Sci U S A, 2009 Apr 28. PMID 19369198, Free PMC Article
  3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC108884

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of HAUS complex ISO
Inferred from Sequence Orthology
more info
  
part_of HAUS complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nuclear microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
HAUS augmin-like complex subunit 8
Names
HEC1/NDC80-interacting centrosome-associated protein 1
sarcoma antigen NY-SAR-48 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024971.2 → NP_001020142.2  HAUS augmin-like complex subunit 8

    See identical proteins and their annotated locations for NP_001020142.2

    Status: VALIDATED

    Source sequence(s)
    BF412974, BQ207735, CB691625, DY317896
    UniProtKB/Swiss-Prot
    Q5BK57
    UniProtKB/TrEMBL
    A6K9R7
    Conserved Domains (1) summary
    TIGR02168
    Location:135 → 346
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    17964813..17979313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771077.4 → XP_008769299.1  HAUS augmin-like complex subunit 8 isoform X4

    UniProtKB/TrEMBL
    A6K9R7
    Conserved Domains (1) summary
    TIGR02168
    Location:134 → 319
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_039094283.2 → XP_038950211.1  HAUS augmin-like complex subunit 8 isoform X2

    UniProtKB/TrEMBL
    A6K9R7

  3. XM_008771076.4 → XP_008769298.1  HAUS augmin-like complex subunit 8 isoform X3

    UniProtKB/TrEMBL
    A6K9R7
    Conserved Domains (1) summary
    TIGR02168
    Location:165 → 376
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_063275149.1 → XP_063131219.1  HAUS augmin-like complex subunit 8 isoform X6

  5. XM_008771074.4 → XP_008769296.1  HAUS augmin-like complex subunit 8 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JUK5, A6K9R7
    Related
    ENSRNOP00000069134.2
    Conserved Domains (1) summary
    TIGR02168
    Location:166 → 377
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. XM_039094287.2 → XP_038950215.1  HAUS augmin-like complex subunit 8 isoform X5

    UniProtKB/TrEMBL
    A0A8I5YCB2

  7. XM_039094286.2 → XP_038950214.1  HAUS augmin-like complex subunit 8 isoform X5

    UniProtKB/TrEMBL
    A0A8I5YCB2

  8. XM_063275147.1 → XP_063131217.1  HAUS augmin-like complex subunit 8 isoform X5

  9. XM_063275146.1 → XP_063131216.1  HAUS augmin-like complex subunit 8 isoform X5

  10. XM_063275148.1 → XP_063131218.1  HAUS augmin-like complex subunit 8 isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BK57.2 GenPept UniProtKB/Swiss-Prot:Q5BK57

Gene LinkOut

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