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Rpl18a ribosomal protein L18A [ Rattus norvegicus (Norway rat) ]

Gene ID: 290641, updated on 2-May-2024

Summary

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Official Symbol
Rpl18aprovided by RGD
Official Full Name
ribosomal protein L18Aprovided by RGD
Primary source
RGD:1302976
See related
Ensembl:ENSRNOG00000018795 AllianceGenome:RGD:1302976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be a structural constituent of ribosome. Involved in response to antineoplastic agent. Located in ribosome. Part of cytosolic large ribosomal subunit. Is active in postsynaptic density. Biomarker of alcohol use disorder. Orthologous to human RPL18A (ribosomal protein L18a). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 4484.6), Thymus (RPKM 4155.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rpl18a in Genome Data Viewer
Location:
16p14
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18576467..18578653)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18542555..18544578)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20293277..20295283)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 1S Neighboring gene uncharacterized LOC134482467 Neighboring gene small nucleolar RNA SNORA68 Neighboring gene solute carrier family 5 member 5 Neighboring gene uncharacterized LOC134482469 Neighboring gene coiled-coil domain containing 124

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The primary structure of rat ribosomal protein L18a. Aoyama Y, et al. FEBS Lett, 1989 Apr 24. PMID 2541017
  2. Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 60 S ribosomal subunit proteins La, Lb, Lf, P1, P2, L13', L14, L18', L20, and L38. Tsurugi K, et al. J Biol Chem, 1978 Feb 10. PMID 621213
  3. Differential expression of diacylglycerol kinase iota and L18A mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding ANA rats. Sommer W, et al. Mol Psychiatry, 2001 Jan. PMID 11244494
  4. Isolation of cDNAs representing dithiolethione-responsive genes. Primiano T, et al. Carcinogenesis, 1996 Nov. PMID 8968041
  5. The primary structures of rat ribosomal proteins: the characterization of the cDNAs for S21 and L39, corrections in the sequences of L7 and L18a, and the identification of L33. Chan YL, et al. Biochem Biophys Res Commun, 1995 Aug 24. PMID 7654221

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC72957

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to antineoplastic agent IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL20
Names
60S ribosomal protein L18a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212510.3 → NP_997675.1  large ribosomal subunit protein eL20

    See identical proteins and their annotated locations for NP_997675.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    P62718
    UniProtKB/TrEMBL
    A6K9Y4, F1M0K6
    Related
    ENSRNOP00000025421.4, ENSRNOT00000025421.7
    Conserved Domains (1) summary
    COG2157
    Location:69 → 153
    RPL20A; Ribosomal protein L20A (L18A) [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    18576467..18578653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275155.1 → XP_063131225.1  large ribosomal subunit protein eL20 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AM85, A6K9Y3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62718.1 GenPept UniProtKB/Swiss-Prot:P62718

Gene LinkOut

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