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Mpv17l2 MPV17 mitochondrial inner membrane protein like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290645, updated on 13-Apr-2024

Summary

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Official Symbol
Mpv17l2provided by RGD
Official Full Name
MPV17 mitochondrial inner membrane protein like 2provided by RGD
Primary source
RGD:1308064
See related
Ensembl:ENSRNOG00000019394 AllianceGenome:RGD:1308064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308064
Summary
Predicted to be involved in mitochondrial ribosome assembly and positive regulation of mitochondrial translation. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Orthologous to human MPV17L2 (MPV17 mitochondrial inner membrane protein like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 166.5), Kidney (RPKM 122.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16p14
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18713690..18718191)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18680106..18684212)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20432734..20435125)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482470 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene IFI30, lysosomal thiol reductase Neighboring gene RAB3A, member RAS oncogene family Neighboring gene phosphodiesterase 4C Neighboring gene colon, intestine and stomach enriched 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MPV17L2 is required for ribosome assembly in mitochondria. Dalla Rosa I, et al. Nucleic Acids Res, 2014 Jul. PMID 24948607, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mitochondrial ribosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial ribosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mpv17-like protein 2
Names
MPV17 mitochondrial membrane protein-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106072.3 → NP_001099542.1  mpv17-like protein 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001099542.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6KA03, D4A9N8
    Related
    ENSRNOP00000026271.6, ENSRNOT00000026271.7
    Conserved Domains (1) summary
    pfam04117
    Location:124 → 186
    Mpv17_PMP22; Mpv17 / PMP22 family

  2. NM_001399440.1 → NP_001386369.1  mpv17-like protein 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    Conserved Domains (1) summary
    pfam04117
    Location:122 → 183
    Mpv17_PMP22; Mpv17 / PMP22 family

  3. NM_001399441.1 → NP_001386370.1  mpv17-like protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    Conserved Domains (1) summary
    pfam04117
    Location:58 → 119
    Mpv17_PMP22; Mpv17 / PMP22 family

  4. NM_001399443.1 → NP_001386372.1  mpv17-like protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    Conserved Domains (1) summary
    pfam04117
    Location:58 → 119
    Mpv17_PMP22; Mpv17 / PMP22 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    18713690..18718191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_005494566.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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