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Crlf1 cytokine receptor-like factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290655, updated on 5-Mar-2024

Summary

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Official Symbol
Crlf1provided by RGD
Official Full Name
cytokine receptor-like factor 1provided by RGD
Primary source
RGD:1311371
See related
Ensembl:ENSRNOG00000020030 AllianceGenome:RGD:1311371
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cytokine binding activity and cytokine receptor activity. Predicted to contribute to ciliary neurotrophic factor receptor binding activity and cytokine activity. Predicted to be involved in several processes, including cytokine-mediated signaling pathway; negative regulation of motor neuron apoptotic process; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to act upstream of or within ureteric bud development. Predicted to be part of CRLF-CLCF1 complex and receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in cold-induced sweating syndrome 1. Orthologous to human CRLF1 (cytokine receptor like factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 95.5), Brain (RPKM 40.2) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Crlf1 in Genome Data Viewer
Location:
16p14
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18958695..18970026, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18924722..18936049, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20675042..20686365, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 Neighboring gene required for excision 1-B domain containing Neighboring gene transmembrane protein 59-like Neighboring gene kelch-like family member 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene. Knappskog PM, et al. Am J Hum Genet, 2003 Feb. PMID 12509788, Free PMC Article
  2. Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo. Forger NG, et al. J Neurosci, 2003 Oct 1. PMID 14523086, Free PMC Article
  3. CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. Elson GC, et al. Nat Neurosci, 2000 Sep. PMID 10966616
  4. Characterizing the new transcription regulator protein p60TRP. Heese K, et al. J Cell Biochem, 2004 Apr 1. PMID 15034937
  5. Spatial gene expression in the T-stage mouse metanephros. Caruana G, et al. Gene Expr Patterns, 2006 Oct. PMID 16545622

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to ciliary neurotrophic factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to cytokine activity ISO
Inferred from Sequence Orthology
more info
  
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
  
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of motor neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
  
involved_in ureteric bud development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of CRLF-CLCF1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CRLF-CLCF1 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytokine receptor-like factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106074.1 → NP_001099544.1  cytokine receptor-like factor 1 precursor

    See identical proteins and their annotated locations for NP_001099544.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474031
    UniProtKB/TrEMBL
    A6KA48
    Conserved Domains (2) summary
    cd00063
    Location:239 → 341
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:136 → 231
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    18958695..18970026 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094330.2 → XP_038950258.1  cytokine receptor-like factor 1 isoform X1

    Conserved Domains (2) summary
    cd00063
    Location:239 → 341
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:136 → 231
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_039094331.2 → XP_038950259.1  cytokine receptor-like factor 1 isoform X2

    Conserved Domains (2) summary
    cd00063
    Location:239 → 341
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:136 → 231
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_006252874.5 → XP_006252936.1  cytokine receptor-like factor 1 isoform X4

    Conserved Domains (2) summary
    cd00063
    Location:239 → 341
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:136 → 231
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. XM_006252872.5 → XP_006252934.1  cytokine receptor-like factor 1 isoform X3

    UniProtKB/TrEMBL
    D3ZIV9
    Related
    ENSRNOP00000056846.3
    Conserved Domains (2) summary
    cd00063
    Location:239 → 341
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:136 → 231
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. XM_039094332.2 → XP_038950260.1  cytokine receptor-like factor 1 isoform X5

    Conserved Domains (2) summary
    cd00063
    Location:239 → 341
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:136 → 231
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein Strain
Heading Accession and Version

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