Cers1 ceramide synthase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cers1provided by RGD
Official Full Name: ceramide synthase 1provided by RGD
Primary source: RGD:1305974
See related: Ensembl:ENSRNOG00000067124 AllianceGenome:RGD:1305974
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lass1
Summary: This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The orthologous human protein has been shown to regulate C18-ceramide (N-stearoyl-sphinganine) synthesis. The protein is expressed from a bicistronic mRNA which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2009]
Expression: Biased expression in Brain (RPKM 101.2), Muscle (RPKM 53.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p14

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (19131271..19146480, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (19097309..19112519, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (20845580..20860789, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest expression of enzymes involved in sphingolipid metabolism in skeletal muscle are regulated by dietary factors; caloric restriction up-regulates expression of Cers1 and Cers2 but down-regulates serine palmitoyltransferases (Spt1, Spt2).
Title: Modulation of sphingolipid metabolism with calorie restriction enhances insulin action in skeletal muscle.
Cloning and sequence analysis revealed that this transcript contains two nonoverlapping open reading frames (ORFs), LASS1 and GDF1, which are quite different to the predicted sequences in GenBank (accession number XM_224734 and XM_224733).
Title: Cloning and characterization of a LASS1-GDF1 transcript in rat cerebral cortex: conservation of a bicistronic structure.

Submit: New GeneRIF Correction

General gene information

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Markers

RH139099 (e-PCR)
- UniSTS:221185

AI385651 (e-PCR)
- UniSTS:159770

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables sphingosine N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine N-acyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-A	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dithiothreitol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mycotoxin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in sphingolipid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ceramide synthase 1

Names: LAG1 homolog, ceramide synthase 1; LAG1 longevity assurance homolog 1; longevity assurance homolog 1; longevity assurance-like protein 1

NP_001037695.1

EC 2.3.1.299

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.