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Dctd dCMP deaminase [ Rattus norvegicus (Norway rat) ]

Gene ID: 290741, updated on 11-Apr-2024

Summary

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Official Symbol
Dctdprovided by RGD
Official Full Name
dCMP deaminaseprovided by RGD
Primary source
RGD:1359671
See related
Ensembl:ENSRNOG00000013215 AllianceGenome:RGD:1359671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dCMP deaminase activity and identical protein binding activity. Predicted to be involved in dTMP biosynthetic process and dUMP biosynthetic process. Orthologous to human DCTD (dCMP deaminase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 61.9), Adrenal (RPKM 52.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dctd in Genome Data Viewer
Location:
16q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (50799699..50831398, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (44066952..44098654, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (47177144..47222850, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552563 Neighboring gene uncharacterized LOC134482500 Neighboring gene macrophage migration inhibitory factor, pseudogene 4 Neighboring gene uncharacterized LOC120097446 Neighboring gene ribosomal protein S15a, pseudogene 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Properties of an affinity-column-purified human deoxycytidylate deaminase. Maley GF, et al. Biochim Biophys Acta, 1993 Mar 5. PMID 8448179
  2. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
  3. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables dCMP deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dCMP deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables deoxyribonucleoside 5'-monophosphate N-glycosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables deoxyribonucleoside 5'-monophosphate N-glycosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables deoxyribonucleoside 5'-monophosphate N-glycosidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytidine deamination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleoside salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside salvage ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleoside salvage ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
deoxycytidylate deaminase
NP_001013904.2
NP_001154984.1
XP_038950302.1
XP_038950304.1
XP_063131299.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013882.2 → NP_001013904.2  deoxycytidylate deaminase isoform 1

    See identical proteins and their annotated locations for NP_001013904.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
    Source sequence(s)
    BC087138, EV776012
    UniProtKB/TrEMBL
    A0A0A0MXX3, A6JPJ8
    Conserved Domains (1) summary
    cd01286
    Location:23 → 144
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

  2. NM_001161512.1 → NP_001154984.1  deoxycytidylate deaminase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and lacks an alternate exon in the 3' coding region that causes a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC087138, BP504069, DY317307
    UniProtKB/TrEMBL
    D3ZXS5
    Related
    ENSRNOP00000056214.3, ENSRNOT00000059459.5
    Conserved Domains (1) summary
    cd01286
    Location:23 → 126
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    50799699..50831398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094376.1 → XP_038950304.1  deoxycytidylate deaminase isoform X3

    UniProtKB/TrEMBL
    A0A8I6ATK1
    Related
    ENSRNOP00000095478.1, ENSRNOT00000118509.1
    Conserved Domains (1) summary
    cl00269
    Location:23 → 87
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

  2. XM_039094374.1 → XP_038950302.1  deoxycytidylate deaminase isoform X1

    UniProtKB/TrEMBL
    A0A0A0MXX3, A6JPJ8
    Related
    ENSRNOP00000017670.5, ENSRNOT00000017670.9
    Conserved Domains (1) summary
    cd01286
    Location:23 → 144
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

  3. XM_063275229.1 → XP_063131299.1  deoxycytidylate deaminase isoform X2

    UniProtKB/TrEMBL
    D3ZXS5

RNA

  1. XR_010058286.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M9G0.1 GenPept UniProtKB/Swiss-Prot:Q5M9G0

Gene LinkOut

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