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Tusc3 tumor suppressor candidate 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290783, updated on 5-Mar-2024

Summary

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Official Symbol
Tusc3provided by RGD
Official Full Name
tumor suppressor candidate 3provided by RGD
Primary source
RGD:1303318
See related
Ensembl:ENSRNOG00000013061 AllianceGenome:RGD:1303318
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable magnesium ion transmembrane transporter activity and oligosaccharyltransferase complex binding activity. Predicted to be involved in cognition; magnesium ion transport; and protein N-linked glycosylation via asparagine. Predicted to be located in mitochondrion. Predicted to be part of oligosaccharyltransferase complex. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TUSC3 (tumor suppressor candidate 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 584.1), Kidney (RPKM 216.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tusc3 in Genome Data Viewer
Location:
16q12.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (59899642..60048813, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (53196195..53345241, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (56248125..56396491)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10A, pseudogene 10 Neighboring gene SMAD family member 2, pseudogene 1 Neighboring gene uncharacterized LOC134482387 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tumor suppressor candidate TUSC3 expression during rat testis maturation. Khalid AM, et al. Biosci Biotechnol Biochem, 2013. PMID 24096664
  2. Mammalian cells lacking either the cotranslational or posttranslocational oligosaccharyltransferase complex display substrate-dependent defects in asparagine linked glycosylation. Cherepanova NA, et al. Sci Rep, 2016 Feb 11. PMID 26864433, Free PMC Article
  3. Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22. MacGrogan D, et al. Genomics, 1996 Jul 1. PMID 8661104
  4. Oligosaccharyltransferase-subunit mutations in nonsyndromic mental retardation. Molinari F, et al. Am J Hum Genet, 2008 May. PMID 18455129, Free PMC Article
  5. Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Zhou H, et al. Proc Natl Acad Sci U S A, 2009 Sep 15. PMID 19717468, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94243

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cognition ISO
Inferred from Sequence Orthology
more info
  
involved_in cognition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in magnesium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in magnesium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in magnesium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in magnesium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation via asparagine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of oligosaccharyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tumor suppressor candidate 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004212.1 → NP_001004212.1  tumor suppressor candidate 3 precursor

    See identical proteins and their annotated locations for NP_001004212.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079193
    UniProtKB/TrEMBL
    A0A0G2KAE2, F7EPX8, Q6AY49
    Related
    ENSRNOP00000017452.4, ENSRNOT00000017452.6
    Conserved Domains (2) summary
    cd02947
    Location:73 → 183
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    pfam04756
    Location:179 → 323
    OST3_OST6; OST3 / OST6 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    59899642..60048813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771294.3 → XP_008769516.1  tumor suppressor candidate 3 isoform X3

    UniProtKB/TrEMBL
    A0A0G2KAE2, A0A8I6AVS1
    Related
    ENSRNOP00000098003.1
    Conserved Domains (2) summary
    cd02947
    Location:73 → 183
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    pfam04756
    Location:179 → 293
    OST3_OST6; OST3 / OST6 family

  2. XM_039094389.2 → XP_038950317.1  tumor suppressor candidate 3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2KAE2

  3. XM_039094388.2 → XP_038950316.1  tumor suppressor candidate 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2KAE2
    Conserved Domains (1) summary
    pfam04756
    Location:54 → 342
    OST3_OST6; OST3 / OST6 family, transporter family
Nucleotide Protein Strain
Heading Accession and Version

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