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Erlin2 ER lipid raft associated 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290823, updated on 11-Apr-2024

Summary

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Official Symbol
Erlin2provided by RGD
Official Full Name
ER lipid raft associated 2provided by RGD
Primary source
RGD:1309010
See related
Ensembl:ENSRNOG00000013763 AllianceGenome:RGD:1309010
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Spfh2; RGD1309010
Summary
Predicted to enable cholesterol binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in SREBP signaling pathway; negative regulation of lipid biosynthetic process; and ubiquitin-dependent ERAD pathway. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum; and membrane raft. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 18. Orthologous to human ERLIN2 (ER lipid raft associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 215.7), Adrenal (RPKM 102.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16q12.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (71720486..71736999, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (65017654..65034184, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (69179005..69195452, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482406 Neighboring gene uncharacterized LOC120097504 Neighboring gene pyridoxal phosphate binding protein Neighboring gene zinc finger protein 703 Neighboring gene uncharacterized LOC108348410 Neighboring gene ribosomal protein L21 like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER. Browman DT, et al. J Cell Sci, 2006 Aug 1. PMID 16835267
  2. An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors. Pearce MM, et al. J Biol Chem, 2009 Apr 17. PMID 19240031, Free PMC Article
  3. Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis. Huber MD, et al. J Cell Biol, 2013 Nov 11. PMID 24217618, Free PMC Article
  4. Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production. Teranishi Y, et al. Biochem Biophys Res Commun, 2012 Aug 3. PMID 22771797
  5. SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells. Pearce MM, et al. J Biol Chem, 2007 Jul 13. PMID 17502376

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a novel brain gamma-secretase associated protein , erlin-2, that resides in detergent resistant membranes and affects amyloid beta-peptide production.
    Title: Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.
  2. Results suggest that this novel SPFH1/2 complex is a recognition factor that targets IP(3)Rs and perhaps other substrates for ERAD.
    Title: An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in SREBP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SREBP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
erlin-2
Names
SPFH domain family, member 2
SPFH domain-containing protein 2
endoplasmic reticulum lipid raft-associated protein 2
stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106088.2 → NP_001099558.1  erlin-2

    See identical proteins and their annotated locations for NP_001099558.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168668
    UniProtKB/Swiss-Prot
    B5DEH2
    Related
    ENSRNOP00000018973.5, ENSRNOT00000018973.7
    Conserved Domains (1) summary
    cd03406
    Location:16 → 308
    SPFH_like_u3; Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    71720486..71736999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771324.4 → XP_008769546.1  erlin-2 isoform X1

    See identical proteins and their annotated locations for XP_008769546.1

    UniProtKB/Swiss-Prot
    B5DEH2
    Conserved Domains (1) summary
    cd03406
    Location:16 → 308
    SPFH_like_u3; Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. XM_008771323.4 → XP_008769545.1  erlin-2 isoform X1

    See identical proteins and their annotated locations for XP_008769545.1

    UniProtKB/Swiss-Prot
    B5DEH2
    Conserved Domains (1) summary
    cd03406
    Location:16 → 308
    SPFH_like_u3; Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5DEH2.1 GenPept UniProtKB/Swiss-Prot:B5DEH2

Gene LinkOut

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