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Ash2l ASH2 like histone lysine methyltransferase complex subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 290829, updated on 5-Mar-2024

Summary

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Official Symbol
Ash2lprovided by RGD
Official Full Name
ASH2 like histone lysine methyltransferase complex subunitprovided by RGD
Primary source
RGD:1305632
See related
Ensembl:ENSRNOG00000014875 AllianceGenome:RGD:1305632
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable beta-catenin binding activity and transcription cis-regulatory region binding activity. Predicted to contribute to histone methyltransferase activity (H3-K4 specific). Predicted to be involved in histone H3-K4 methylation; positive regulation of cell population proliferation; and response to estrogen. Predicted to act upstream of or within cellular response to DNA damage stimulus and positive regulation of transcription by RNA polymerase II. Predicted to be located in euchromatin and nucleus. Predicted to be part of MLL1 complex; MLL3/4 complex; and Set1C/COMPASS complex. Biomarker of schizophrenia. Orthologous to human ASH2L (ASH2 like, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 357.7), Thymus (RPKM 167.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16q12.4
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (72943527..72966791)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (66242205..66264064)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (71011315..71033171)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 5 Neighboring gene potassium calcium-activated channel subfamily U member 1 Neighboring gene uncharacterized LOC120097390 Neighboring gene steroidogenic acute regulatory protein Neighboring gene LSM1 homolog, mRNA degradation associated Neighboring gene BAG cochaperone 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The human trithorax protein hASH2 functions as an oncoprotein. Lüscher-Firzlaff J, et al. Cancer Res, 2008 Feb 1. PMID 18245475
  2. Prenatal MAM administration affects histone H3 methylation in postnatal life in the rat medial prefrontal cortex. Maćkowiak M, et al. Eur Neuropsychopharmacol, 2014 Feb. PMID 23932495
  3. Identification of the MLL2 complex as a coactivator for estrogen receptor alpha. Mo R, et al. J Biol Chem, 2006 Jun 9. PMID 16603732
  4. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. Patel A, et al. J Biol Chem, 2009 Sep 4. PMID 19556245, Free PMC Article
  5. Ash2l interacts with Tbx1 and is required during early embryogenesis. Stoller JZ, et al. Exp Biol Med (Maywood), 2010 May. PMID 20463296, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL1/2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL3/4 complex ISO
Inferred from Sequence Orthology
more info
  
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set1C/COMPASS complex ISO
Inferred from Sequence Orthology
more info
  
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
  
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
set1/Ash2 histone methyltransferase complex subunit ASH2
Names
ash2 (absent, small, or homeotic)-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106089.1 → NP_001099559.1  set1/Ash2 histone methyltransferase complex subunit ASH2

    See identical proteins and their annotated locations for NP_001099559.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473970
    UniProtKB/TrEMBL
    A0A8I6ASM7, A6IW01
    Conserved Domains (2) summary
    cd15583
    Location:96 → 145
    PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
    cd12872
    Location:387 → 578
    SPRY_Ash2; SPRY domain in Ash2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    72943527..72966791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253303.4 → XP_006253365.1  set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ASM7, D3ZTV7
    Related
    ENSRNOP00000020181.5
    Conserved Domains (2) summary
    cd15583
    Location:96 → 145
    PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
    cd12872
    Location:393 → 584
    SPRY_Ash2; SPRY domain in Ash2

  2. XM_006253304.5 → XP_006253366.1  set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JT90
    Related
    ENSRNOP00000094978.1
    Conserved Domains (2) summary
    cd15583
    Location:7 → 56
    PHD_ash2p_like; PHD finger found in Schizosaccharomyces pombe Set1 complex component ash2 (spAsh2p) and similar proteins
    cd12872
    Location:304 → 495
    SPRY_Ash2; SPRY domain in Ash2

  3. XM_063275243.1 → XP_063131313.1  set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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