Gins4 GINS complex subunit 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gins4provided by RGD
Official Full Name: GINS complex subunit 4provided by RGD
Primary source: RGD:1307397
See related: Ensembl:ENSRNOG00000018040 AllianceGenome:RGD:1307397
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307397; 2810037c03rik
Summary: Predicted to be involved in double-strand break repair via break-induced replication. Predicted to act upstream of or within inner cell mass cell proliferation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CMG complex and GINS complex. Orthologous to human GINS4 (GINS complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 97.7), Testes (RPKM 87.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.5

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (75489990..75502455)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (68787572..68799938)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (73584412..73596808)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH141335 (e-PCR)
- UniSTS:223331

RH139000 (e-PCR)
- UniSTS:221086

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in DNA unwinding involved in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA unwinding involved in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA-templated DNA replication	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via break-induced replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner cell mass cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner cell mass cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CMG complex	IEA Inferred from Electronic Annotation more info
part_of CMG complex	ISO Inferred from Sequence Orthology more info
part_of CMG complex	ISS Inferred from Sequence or Structural Similarity more info
part_of GINS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GINS complex	IEA Inferred from Electronic Annotation more info
part_of GINS complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA replication complex GINS protein SLD5

Names: GINS complex subunit 4 (Sld5 homolog); SLD5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030027.1 → NP_001025198.1 DNA replication complex GINS protein SLD5

See identical proteins and their annotated locations for NP_001025198.1

Status: PROVISIONAL

Source sequence(s)

BC099741

UniProtKB/Swiss-Prot

Q499W2

UniProtKB/TrEMBL

A6IW42, G3V8B5

Related

ENSRNOP00000024301.3, ENSRNOT00000024301.5

Conserved Domains (2) summary

cd11711
Location:26 → 146

GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5

cd21692
Location:165 → 223

GINS_B_Sld5; beta-strand (B) domain of GINS complex protein Sld5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

75489990..75502455

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275250.1 → XP_063131320.1 DNA replication complex GINS protein SLD5 isoform X2
XM_006253313.5 → XP_006253375.1 DNA replication complex GINS protein SLD5 isoform X1

UniProtKB/TrEMBL

A6IW42, G3V8B5

Conserved Domains (3) summary

cd11711
Location:26 → 121

GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5

COG5086
Location:14 → 198

COG5086; Uncharacterized conserved protein [Function unknown]

pfam16922
Location:140 → 198

SLD5_C; DNA replication complex GINS protein SLD5 C-terminus