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Gpat4 glycerol-3-phosphate acyltransferase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290843, updated on 5-Mar-2024

Summary

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Official Symbol
Gpat4provided by RGD
Official Full Name
glycerol-3-phosphate acyltransferase 4provided by RGD
Primary source
RGD:1310520
See related
Ensembl:ENSRNOG00000018077 AllianceGenome:RGD:1310520
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Agpat6; RGD1310520
Summary
Predicted to enable glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in acyl-CoA metabolic process; phosphatidylcholine biosynthetic process; and triglyceride biosynthetic process. Predicted to act upstream of or within several processes, including acylglycerol metabolic process; glandular epithelial cell maturation; and lactation. Predicted to be located in endoplasmic reticulum and membrane. Orthologous to human GPAT4 (glycerol-3-phosphate acyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 464.7), Thymus (RPKM 174.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpat4 in Genome Data Viewer
Location:
16q12.5
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (75515935..75555431)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (68819031..68852903)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (73615949..73649769)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene golgin A7 Neighboring gene GINS complex subunit 4 Neighboring gene NK6 homeobox 3 Neighboring gene ankyrin 1 Neighboring gene uncharacterized LOC120097525

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity. Vergnes L, et al. J Lipid Res, 2006 Apr. PMID 16436371, Free PMC Article
  2. Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium. Beigneux AP, et al. J Lipid Res, 2006 Apr. PMID 16449762, Free PMC Article
  3. AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. Chen YQ, et al. J Biol Chem, 2008 Apr 11. PMID 18238778, Free PMC Article
  4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycerol-3-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within diacylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glandular epithelial cell maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lactation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mammary gland development ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylcholine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycerol-3-phosphate acyltransferase 6
Names
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
lysophosphatidic acid acyltransferase zeta
putative lysophosphatidic acid acyltransferase
NP_001041314.1
XP_038950336.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001047849.1 → NP_001041314.1  glycerol-3-phosphate acyltransferase 6

    See identical proteins and their annotated locations for NP_001041314.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ480750
    UniProtKB/TrEMBL
    A0A8I6AJ01, A6IW43, B1WBM4, Q0ZFS7
    Related
    ENSRNOP00000024392.4, ENSRNOT00000024392.6
    Conserved Domains (1) summary
    cd07991
    Location:218 → 427
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    75515935..75555431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094408.2 → XP_038950336.1  glycerol-3-phosphate acyltransferase 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZT34, A0A8I6AJ01
    Related
    ENSRNOP00000082143.1
    Conserved Domains (1) summary
    cd07991
    Location:189 → 397
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
Nucleotide Protein Strain
Heading Accession and Version

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