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Prpf4b pre-mRNA processing factor 4B [ Rattus norvegicus (Norway rat) ]

Gene ID: 291078, updated on 2-May-2024

Summary

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Official Symbol
Prpf4bprovided by RGD
Official Full Name
pre-mRNA processing factor 4Bprovided by RGD
Primary source
RGD:1307784
See related
Ensembl:ENSRNOG00000016705 AllianceGenome:RGD:1307784
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be located in chromosome and nuclear speck. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleus. Orthologous to human PRPF4B (pre-mRNA processing factor 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 297.0), Spleen (RPKM 261.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prpf4b in Genome Data Viewer
Location:
17p12
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (30190721..30230153, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (29985343..30020285, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (30680454..30714542, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene enoyl-Coenzyme A delta isomerase 3 Neighboring gene testis expressed 56 Neighboring gene family with sequence similarity 217, member A Neighboring gene high mobility group box 1, pseudogene 2 Neighboring gene family with sequence similarity 50, member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Capturing novel mouse genes encoding chromosomal and other nuclear proteins. Tate P, et al. J Cell Sci, 1998 Sep. PMID 9701556
  2. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article
  3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
  5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spliceosomal snRNP assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal snRNP assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spliceosomal tri-snRNP complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in spliceosomal tri-snRNP complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in spliceosomal tri-snRNP complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IEA
Inferred from Electronic Annotation
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase PRP4 homolog
Names
PRP4 pre-mRNA processing factor 4 homolog B
PRP4 pre-mRNA-processing factor 4 homolog
NP_001011923.1
XP_038951416.1
XP_038951417.1
XP_063132231.1
XP_063132232.1
XP_063132233.1
XP_063132234.1
XP_063132235.1
XP_063132236.1
XP_063132237.1
XP_063132238.1
XP_063132239.1
XP_063132240.1
XP_063132241.1
XP_063132242.1
XP_063132243.1
XP_063132244.1
XP_063132245.1
XP_063132246.1
XP_063132247.1
XP_063132248.1
XP_063132249.1
XP_063132250.1
XP_063132251.1
XP_063132252.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011923.1 → NP_001011923.1  serine/threonine-protein kinase PRP4 homolog

    See identical proteins and their annotated locations for NP_001011923.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085927
    UniProtKB/Swiss-Prot
    Q5RKH1
    UniProtKB/TrEMBL
    A6J7F3
    Related
    ENSRNOP00000072106.2, ENSRNOT00000081993.2
    Conserved Domains (2) summary
    PTZ00108
    Location:171 → 396
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd14135
    Location:686 → 1003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    30190721..30230153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095488.2 → XP_038951416.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1
    UniProtKB/TrEMBL
    A6J7F3
    Conserved Domains (2) summary
    PTZ00108
    Location:171 → 396
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd14135
    Location:686 → 1003
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

  2. XM_063276166.1 → XP_063132236.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  3. XM_063276167.1 → XP_063132237.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  4. XM_063276181.1 → XP_063132251.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  5. XM_063276180.1 → XP_063132250.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  6. XM_063276178.1 → XP_063132248.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  7. XM_063276168.1 → XP_063132238.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  8. XM_063276162.1 → XP_063132232.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  9. XM_063276164.1 → XP_063132234.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  10. XM_063276165.1 → XP_063132235.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  11. XM_063276163.1 → XP_063132233.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  12. XM_063276161.1 → XP_063132231.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  13. XM_063276169.1 → XP_063132239.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  14. XM_063276179.1 → XP_063132249.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  15. XM_063276171.1 → XP_063132241.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  16. XM_063276177.1 → XP_063132247.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  17. XM_063276170.1 → XP_063132240.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  18. XM_063276176.1 → XP_063132246.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  19. XM_063276175.1 → XP_063132245.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  20. XM_063276174.1 → XP_063132244.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  21. XM_063276172.1 → XP_063132242.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  22. XM_063276173.1 → XP_063132243.1  serine/threonine-protein kinase PRP4 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5RKH1

  23. XM_063276182.1 → XP_063132252.1  serine/threonine-protein kinase PRP4 homolog isoform X2

  24. XM_039095489.2 → XP_038951417.1  serine/threonine-protein kinase PRP4 homolog isoform X3

    Conserved Domains (1) summary
    PTZ00108
    Location:171 → 396
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5RKH1.1 GenPept UniProtKB/Swiss-Prot:Q5RKH1

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