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Hecw1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291209, updated on 2-May-2024

Summary

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Symbol
Hecw1provided by RGD
Full Name
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1provided by RGD
Primary source
RGD:1561038
See related
Ensembl:ENSRNOG00000016046 AllianceGenome:RGD:1561038
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561038
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane transporter activity; and regulation of dendrite morphogenesis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 147.4), Testes (RPKM 14.8) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
17q12.1
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (55366904..55780028)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (50671239..51084536)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (53229997..53777474)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit alpha 2 Neighboring gene mitochondrial ribosomal protein L32 Neighboring gene RB binding protein 4, chromatin remodeling factor, pseudogene 2 Neighboring gene 40S ribosomal protein S19 pseudogene Neighboring gene Y-box-binding protein 1-like Neighboring gene AT-rich interaction domain 4B Neighboring gene geranylgeranyl diphosphate synthase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Circular RNA Hecw1 Regulates the Inflammatory Imbalance in Spinal Cord Injury via miR-3551-3p/LRRTM1 Axis. Ban D, et al. Appl Biochem Biotechnol, 2022 Nov. PMID 35699802
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circular RNA Hecw1 Regulates the Inflammatory Imbalance in Spinal Cord Injury via miR-3551-3p/LRRTM1 Axis.
    Title: Circular RNA Hecw1 Regulates the Inflammatory Imbalance in Spinal Cord Injury via miR-3551-3p/LRRTM1 Axis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HECW1
Names
E3 ubiquitin-protein ligase HECW1-like
NP_001099587.1
XP_008769919.1
XP_017455974.1
XP_017455975.1
XP_017455976.1
XP_017455977.1
XP_017455978.1
XP_017455979.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106117.1 → NP_001099587.1  E3 ubiquitin-protein ligase HECW1

    See identical proteins and their annotated locations for NP_001099587.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474030
    UniProtKB/TrEMBL
    A0A8I6A475, A6K9C5, F1M4Q8
    Related
    ENSRNOP00000021703.5, ENSRNOT00000021703.6
    Conserved Domains (5) summary
    cd08691
    Location:197 → 333
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:818 → 848
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:1262 → 1591
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1238 → 1592
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:57 → 176
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    55366904..55780028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600485.3 → XP_017455974.1  E3 ubiquitin-protein ligase HECW1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A475, A0A8I6AG92, A6K9C4
    Related
    ENSRNOP00000091762.1
    Conserved Domains (5) summary
    cd08691
    Location:206 → 342
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:827 → 857
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:1271 → 1600
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1247 → 1601
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:66 → 185
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

  2. XM_017600489.3 → XP_017455978.1  E3 ubiquitin-protein ligase HECW1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A475

  3. XM_017600487.3 → XP_017455976.1  E3 ubiquitin-protein ligase HECW1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A475

  4. XM_017600490.3 → XP_017455979.1  E3 ubiquitin-protein ligase HECW1 isoform X6

    UniProtKB/TrEMBL
    A0A8I6A475

  5. XM_008771697.4 → XP_008769919.1  E3 ubiquitin-protein ligase HECW1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZQP0, A0A8I6A475
    Related
    ENSRNOP00000080972.1
    Conserved Domains (5) summary
    cd08691
    Location:205 → 341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:826 → 856
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:1270 → 1599
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1246 → 1600
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:65 → 184
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

  6. XM_017600486.3 → XP_017455975.1  E3 ubiquitin-protein ligase HECW1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZQP0, A0A8I6A475
    Conserved Domains (5) summary
    cd08691
    Location:205 → 341
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:826 → 856
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:1270 → 1599
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1246 → 1600
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam16562
    Location:65 → 184
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2

  7. XM_017600488.3 → XP_017455977.1  E3 ubiquitin-protein ligase HECW1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A475, A6K9C6
    Conserved Domains (6) summary
    cd08691
    Location:184 → 320
    C2_NEDL1-like; C2 domain present in NEDL1 (NEDD4-like ubiquitin protein ligase-1)
    smart00456
    Location:995 → 1026
    WW; Domain with 2 conserved Trp (W) residues
    smart00119
    Location:1249 → 1578
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:1225 → 1579
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00397
    Location:806 → 835
    WW; WW domain
    pfam16562
    Location:44 → 163
    HECW_N; N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
Nucleotide Protein Strain
Heading Accession and Version

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