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Rttn rotatin [ Rattus norvegicus (Norway rat) ]

Gene ID: 291377, updated on 30-Mar-2024

Summary

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Official Symbol
Rttnprovided by RGD
Official Full Name
rotatinprovided by RGD
Primary source
RGD:1306706
See related
Ensembl:ENSRNOG00000038200 AllianceGenome:RGD:1306706
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in centriole replication; centriole-centriole cohesion; and ciliary basal body organization. Predicted to act upstream of or within determination of left/right symmetry. Predicted to be located in centrosome. Predicted to be active in centriole and ciliary basal body. Orthologous to human RTTN (rotatin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 87.2), Spleen (RPKM 53.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rttn in Genome Data Viewer
Location:
18q13
Exon count:
52
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (84495813..84673079)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (82220999..82398334)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (86071884..86247486)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ATP synthase peripheral stalk-membrane subunit b, pseudogene 2 Neighboring gene PCNA clamp associated factor, pseudogene 2 Neighboring gene uncharacterized LOC134483073 Neighboring gene prothymosin alpha like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RTTN mutations link primary cilia function to organization of the human cerebral cortex. Kheradmand Kia S, et al. Am J Hum Genet, 2012 Sep 7. PMID 22939636, Free PMC Article
  2. Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos. Faisst AM, et al. Mech Dev, 2002 Apr. PMID 11900971
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole-centriole cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ciliary basal body organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rotatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170436.2 → NP_001163907.2  rotatin

    Status: VALIDATED

    Source sequence(s)
    FN802245, JAXUCZ010000018
    Conserved Domains (1) summary
    pfam14726
    Location:16 → 112
    RTTN_N; Rotatin, an armadillo repeat protein, centriole functioning

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    84495813..84673079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096615.2 → XP_038952543.1  rotatin isoform X1

    Conserved Domains (1) summary
    pfam14726
    Location:16 → 112
    RTTN_N; Rotatin, an armadillo repeat protein, centriole functioning

  2. XM_039096617.2 → XP_038952545.1  rotatin isoform X3

    UniProtKB/TrEMBL
    D3ZS92
    Related
    ENSRNOP00000054965.5
    Conserved Domains (1) summary
    pfam14726
    Location:16 → 112
    RTTN_N; Rotatin, an armadillo repeat protein, centriole functioning

  3. XM_039096616.2 → XP_038952544.1  rotatin isoform X2

    Conserved Domains (1) summary
    pfam14726
    Location:16 → 112
    RTTN_N; Rotatin, an armadillo repeat protein, centriole functioning

  4. XM_063277155.1 → XP_063133225.1  rotatin isoform X4

  5. XM_039096620.2 → XP_038952548.1  rotatin isoform X6

    UniProtKB/TrEMBL
    A0A096MJA7

  6. XM_039096618.2 → XP_038952546.1  rotatin isoform X5

  7. XM_039096619.2 → XP_038952547.1  rotatin isoform X6

    UniProtKB/TrEMBL
    A0A096MJA7
    Related
    ENSRNOP00000068057.2

  8. XM_039096622.2 → XP_038952550.1  rotatin isoform X7

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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