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Rnmt RNA (guanine-7-) methyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 291534, updated on 2-May-2024

Summary

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Official Symbol
Rnmtprovided by RGD
Official Full Name
RNA (guanine-7-) methyltransferaseprovided by RGD
Primary source
RGD:1309242
See related
Ensembl:ENSRNOG00000016698 AllianceGenome:RGD:1309242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity and mRNA (guanine-N7-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of mRNA cap binding activity complex; mRNA cap methyltransferase complex; and receptor complex. Predicted to be active in nucleus. Orthologous to human RNMT (RNA guanine-7 methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 105.0), Brain (RPKM 88.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rnmt in Genome Data Viewer
Location:
18q12.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (64156067..64179601)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (61886230..61909775)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (64084746..64108246)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene tRNA methyltransferase activator subunit 11-2, pseudogene 1 Neighboring gene family with sequence similarity 210, member A Neighboring gene melanocortin 5 receptor Neighboring gene melanocortin 2 receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships. Bujnicki JM, et al. BMC Bioinformatics, 2001. PMID 11472630, Free PMC Article
  2. Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM. Varshney D, et al. Nucleic Acids Res, 2016 Dec 1. PMID 27422871, Free PMC Article
  3. Cap-binding complex (CBC). Gonatopoulos-Pournatzis T, et al. Biochem J, 2014 Jan 15. PMID 24354960, Free PMC Article
  4. RAM/Fam103a1 is required for mRNA cap methylation. Gonatopoulos-Pournatzis T, et al. Mol Cell, 2011 Nov 18. PMID 22099306, Free PMC Article
  5. Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase. Tsukamoto T, et al. Biochem Biophys Res Commun, 1998 Oct 9. PMID 9790902

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94587

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in 7-methylguanosine mRNA capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 7-methylguanosine mRNA capping IEA
Inferred from Electronic Annotation
more info
  
involved_in 7-methylguanosine mRNA capping ISO
Inferred from Sequence Orthology
more info
  
involved_in 7-methylguanosine mRNA capping ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in RNA 5'-cap (guanine-N7)-methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA cap methyltransferase RNMT:RAMAC complex ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA cap methyltransferase RNMT:RAMAC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mRNA capping enzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of mRNA capping enzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mRNA cap guanine-N7 methyltransferase
Names
RG7MT1
mRNA (guanine-N(7)-)-methyltransferase
mRNA cap methyltransferase
NP_001008300.1
XP_006254956.1
XP_006254957.1
XP_006254958.1
XP_038952589.1
XP_063133260.1
XP_063133261.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008299.2 → NP_001008300.1  mRNA cap guanine-N7 methyltransferase

    See identical proteins and their annotated locations for NP_001008300.1

    Status: VALIDATED

    Source sequence(s)
    BC085858, CN543861
    UniProtKB/Swiss-Prot
    Q5U2U7
    UniProtKB/TrEMBL
    A0A8I6AG46, A6IXX3
    Related
    ENSRNOP00000022410.4, ENSRNOT00000022410.5
    Conserved Domains (1) summary
    pfam03291
    Location:124 → 460
    Pox_MCEL; mRNA capping enzyme

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    64156067..64179601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254896.5 → XP_006254958.1  mRNA cap guanine-N7 methyltransferase isoform X2

    See identical proteins and their annotated locations for XP_006254958.1

    UniProtKB/TrEMBL
    A0A8I5Y8Y9, A6IXX4
    Related
    ENSRNOP00000076517.1
    Conserved Domains (2) summary
    COG0500
    Location:156 → 344
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    cl17173
    Location:124 → 405
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_006254894.3 → XP_006254956.1  mRNA cap guanine-N7 methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006254956.1

    UniProtKB/Swiss-Prot
    Q5U2U7
    UniProtKB/TrEMBL
    A0A8I6AG46, A6IXX3
    Conserved Domains (1) summary
    pfam03291
    Location:124 → 460
    Pox_MCEL; mRNA capping enzyme

  3. XM_063277191.1 → XP_063133261.1  mRNA cap guanine-N7 methyltransferase isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y8Y9, A6IXX4

  4. XM_039096661.2 → XP_038952589.1  mRNA cap guanine-N7 methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q5U2U7
    UniProtKB/TrEMBL
    A0A8I6AG46, A6IXX3
    Conserved Domains (1) summary
    pfam03291
    Location:124 → 460
    Pox_MCEL; mRNA capping enzyme

  5. XM_006254895.5 → XP_006254957.1  mRNA cap guanine-N7 methyltransferase isoform X1

    See identical proteins and their annotated locations for XP_006254957.1

    UniProtKB/Swiss-Prot
    Q5U2U7
    UniProtKB/TrEMBL
    A0A8I6AG46, A6IXX3
    Conserved Domains (1) summary
    pfam03291
    Location:124 → 460
    Pox_MCEL; mRNA capping enzyme

  6. XM_063277190.1 → XP_063133260.1  mRNA cap guanine-N7 methyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q5U2U7
    UniProtKB/TrEMBL
    A6IXX3

RNA

  1. XR_005496003.2 RNA Sequence

  2. XR_010059551.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2U7.1 GenPept UniProtKB/Swiss-Prot:Q5U2U7

Gene LinkOut

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