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Kctd16 potassium channel tetramerization domain containing 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291618, updated on 2-May-2024

Summary

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Official Symbol
Kctd16provided by RGD
Official Full Name
potassium channel tetramerization domain containing 16provided by RGD
Primary source
RGD:1559856
See related
Ensembl:ENSRNOG00000069221 AllianceGenome:RGD:1559856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1559856
Summary
Predicted to act upstream of or within regulation of G protein-coupled receptor signaling pathway. Predicted to be located in postsynaptic membrane and presynaptic membrane. Predicted to be part of receptor complex. Orthologous to human KCTD16 (potassium channel tetramerization domain containing 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 425.7), Brain (RPKM 143.7) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Kctd16 in Genome Data Viewer
Location:
18p11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (32417306..32711928)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (32166236..32473067)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (33443362..33730642)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene Yip1 domain family, member 5 Neighboring gene ubiquitin-conjugating enzyme E2C, pseudogene 3 Neighboring gene transfer RNA proline (anticodon AGG) 42 Neighboring gene igE-binding protein-like Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Schwenk J, et al. Nature, 2010 May 13. PMID 20400944

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of presynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein KCTD16
Names
potassium channel tetramerisation domain containing 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172155.1 → NP_001165626.1  BTB/POZ domain-containing protein KCTD16

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8I6A6D0
    Conserved Domains (2) summary
    cd18398
    Location:23 → 125
    BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
    cd22219
    Location:160 → 280
    H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    32417306..32711928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600896.3 → XP_017456385.1  BTB/POZ domain-containing protein KCTD16 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6D0
    Conserved Domains (2) summary
    cd18398
    Location:23 → 125
    BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
    cd22219
    Location:160 → 280
    H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

  2. XM_017600895.3 → XP_017456384.1  BTB/POZ domain-containing protein KCTD16 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6D0
    Related
    ENSRNOP00000087696.1
    Conserved Domains (2) summary
    cd18398
    Location:23 → 125
    BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
    cd22219
    Location:160 → 280
    H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

  3. XM_017600897.3 → XP_017456386.1  BTB/POZ domain-containing protein KCTD16 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6D0
    Conserved Domains (2) summary
    cd18398
    Location:23 → 125
    BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
    cd22219
    Location:160 → 280
    H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

  4. XM_039096706.2 → XP_038952634.1  BTB/POZ domain-containing protein KCTD16 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A6D0
    Conserved Domains (2) summary
    cd18398
    Location:23 → 125
    BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
    cd22219
    Location:160 → 280
    H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16
Nucleotide Protein Strain
Heading Accession and Version

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