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SLC25A5 solute carrier family 25 member 5 [ Homo sapiens (human) ]

Gene ID: 292, updated on 5-Jan-2025

Summary

Official Symbol
SLC25A5provided by HGNC
Official Full Name
solute carrier family 25 member 5provided by HGNC
Primary source
HGNC:HGNC:10991
See related
Ensembl:ENSG00000005022 MIM:300150; AllianceGenome:HGNC:10991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T2; T3; 2F1; AAC2; ANT2
Summary
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in duodenum (RPKM 370.1), small intestine (RPKM 299.2) and 25 other tissues See more
Orthologs
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Genomic context

See SLC25A5 in Genome Data Viewer
Location:
Xq24
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (119468444..119471396)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (117846144..117849097)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (118602407..118605359)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 43 Neighboring gene RNA, 7SL, cytoplasmic 118, pseudogene Neighboring gene Sharpr-MPRA regulatory region 3305 Neighboring gene SLC25A5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20958 Neighboring gene RNY3 pseudogene 16 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29879 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29881 Neighboring gene Sharpr-MPRA regulatory region 9216 Neighboring gene Sharpr-MPRA regulatory region 13316 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:118675673-118676174 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:118676175-118676674 Neighboring gene STING1 ER exit protein 1 Neighboring gene uncharacterized LOC124905208 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:118708298-118708798

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify solute carrier family 25 member 5 (SLC25A5), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify solute carrier family 25 member 5 (SLC25A5), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify solute carrier family 25 member 5 (SLC25A5), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify solute carrier family 25 member 5 (SLC25A5), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of solute carrier family 25, member 5 (SLC25A5) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in B cell differentiation  
involved_in adaptive thermogenesis  
involved_in adenine nucleotide transport PubMed 
involved_in adenine transport  
involved_in cellular response to leukemia inhibitory factor  
involved_in chromosome segregation  
involved_in erythrocyte differentiation  
involved_in mitochondrial ADP transmembrane transport  
involved_in mitochondrial ATP transmembrane transport  
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway PubMed 
involved_in positive regulation of cell population proliferation PubMed 
involved_in positive regulation of mitophagy  
involved_in proton transmembrane transport  
involved_in regulation of mitochondrial membrane permeability  

General protein information

Preferred Names
ADP/ATP translocase 2
Names
adenine nucleotide translocator 2 (fibroblast)
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013262.1 RefSeqGene

    Range
    5045..7997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001152.5NP_001143.2  ADP/ATP translocase 2

    See identical proteins and their annotated locations for NP_001143.2

    Status: REVIEWED

    Source sequence(s)
    BC056160, BC068199, BQ223988, DR759917
    Consensus CDS
    CCDS14578.1
    UniProtKB/Swiss-Prot
    B2RCV1, O43350, P05141
    UniProtKB/TrEMBL
    Q6NVC0
    Related
    ENSP00000360671.4, ENST00000317881.9
    Conserved Domains (2) summary
    PTZ00169
    Location:7296
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:6101
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    119468444..119471396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    117846144..117849097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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