Txnl4b thioredoxin-like 4B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Txnl4bprovided by RGD
Official Full Name: thioredoxin-like 4Bprovided by RGD
Primary source: RGD:1305127
See related: Ensembl:ENSRNOG00000021379 AllianceGenome:RGD:1305127
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305127
Summary: Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of U4/U6 x U5 tri-snRNP complex; U5 snRNP; and spliceosomal complex. Orthologous to human TXNL4B (thioredoxin like 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 41.1), Kidney (RPKM 40.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (54439686..54449777)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (37530157..37539827)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (42101081..42110223, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of U4/U6 x U5 tri-snRNP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U5 snRNP	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: thioredoxin-like protein 4B

Names: Dim1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013891.1 → NP_001013913.1 thioredoxin-like protein 4B

See identical proteins and their annotated locations for NP_001013913.1

Status: PROVISIONAL

Source sequence(s)

BC089962

UniProtKB/TrEMBL

F7FL88, Q5FVI5

Conserved Domains (1) summary

cd02986
Location:10 → 123

DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

54439686..54449777

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006255579.5 → XP_006255641.1 thioredoxin-like protein 4B isoform X1

See identical proteins and their annotated locations for XP_006255641.1

UniProtKB/TrEMBL

F7FL88, Q5FVI5

Related

ENSRNOP00000030193.3

Conserved Domains (1) summary

cd02986
Location:10 → 123

DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...
XM_017601235.3 → XP_017456724.1 thioredoxin-like protein 4B isoform X2

Conserved Domains (1) summary

cl00388
Location:1 → 69

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
XM_063277930.1 → XP_063134000.1 thioredoxin-like protein 4B isoform X1

UniProtKB/TrEMBL

F7FL88, Q5FVI5
XM_063277931.1 → XP_063134001.1 thioredoxin-like protein 4B isoform X2