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Epha6 Eph receptor A6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29202, updated on 2-May-2024

Summary

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Symbol
Epha6provided by RGD
Full Name
Eph receptor A6provided by RGD
Primary source
RGD:1304614
See related
Ensembl:ENSRNOG00000029184 AllianceGenome:RGD:1304614
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ehk2; EHK-2; AABR07033882.1
Summary
Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human EPHA6 (EPH receptor A6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 62.8) See more
Orthologs
human mouse all
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Genomic context

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Location:
11q12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (53226784..54178120)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (39757501..40708901)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (41867607..42843800)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene vesicle trafficking 1, pseudogene 1 Neighboring gene uncharacterized LOC120095545 Neighboring gene acetyl-CoA acetyltransferase 2, pseudogene 1 Neighboring gene uncharacterized LOC134480984 Neighboring gene U7 small nuclear RNA Neighboring gene ADP-ribosylation factor like GTPase 6 Neighboring gene crystallin beta-gamma domain containing 3 Neighboring gene ribosomal oxygenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression. Maisonpierre PC, et al. Oncogene, 1993 Dec. PMID 7504232
  2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ephrin type-A receptor 6
Names
EPH homology kinase 2
tyrosine-protein kinase receptor EHK-2
NP_001406458.1
XP_038944648.1
XP_038944649.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419529.1 → NP_001406458.1  ephrin type-A receptor 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A8I6A6J8
    Related
    ENSRNOP00000087819.1, ENSRNOT00000097751.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    53226784..54178120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088720.2 → XP_038944648.1  ephrin type-A receptor 6 isoform X1

    UniProtKB/Swiss-Prot
    P54758
    Conserved Domains (7) summary
    cd09547
    Location:918 → 981
    SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
    cd00063
    Location:412 → 491
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:583 → 891
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:290 → 384
    fn3; Fibronectin type III domain
    pfam07699
    Location:231 → 269
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam14575
    Location:507 → 585
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1 → 163
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

  2. XM_039088721.2 → XP_038944649.1  ephrin type-A receptor 6 isoform X2

    UniProtKB/Swiss-Prot
    P54758
    UniProtKB/TrEMBL
    F1LQK6
    Related
    ENSRNOP00000049409.6
    Conserved Domains (7) summary
    cd09547
    Location:899 → 962
    SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
    cd00063
    Location:393 → 472
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:564 → 872
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:271 → 365
    fn3; Fibronectin type III domain
    pfam07699
    Location:212 → 250
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam14575
    Location:488 → 566
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1 → 144
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54758.2 GenPept UniProtKB/Swiss-Prot:P54758

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