Cdyl2 chromodomain Y-like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdyl2provided by RGD
Official Full Name: chromodomain Y-like 2provided by RGD
Primary source: RGD:1309548
See related: Ensembl:ENSRNOG00000042888 AllianceGenome:RGD:1309548
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable methylated histone binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to be active in nucleus. Orthologous to human CDYL2 (chromodomain Y like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 72.4), Brain (RPKM 61.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (61500702..61691746, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (44591734..44783258, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (49087131..49222528, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The researchers found evidence that Sry3 is one of the genes associated with the increased risk of spontaneous hypertension Y chromosome phenotype in Wistar Kyoto rats
Title: The Sry3 Y chromosome locus elevates blood pressure and renin-angiotensin system indexes.

Submit: New GeneRIF Correction

General gene information

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Markers

RH135103 (e-PCR)
- UniSTS:218380

d19rat64 (e-PCR)
- UniSTS:121411

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chromodomain Y-like protein 2

Names: chromodomain protein, Y chromosome-like 2; chromodomain protein, Y-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106189.3 → NP_001099659.2 chromodomain Y-like protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A8I6GEJ2

Related

ENSRNOP00000086896.1, ENSRNOT00000117818.1

Conserved Domains (2) summary

cd06558
Location:249 → 445

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

cd18634
Location:6 → 57

CD_CDY; chromodomain of the Chromodomain Y-like protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

61500702..61691746 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097639.2 → XP_038953567.1 chromodomain Y-like protein 2 isoform X2

UniProtKB/TrEMBL

A6IZF6

Conserved Domains (1) summary

cd06558
Location:106 → 302

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_017601238.3 → XP_017456727.1 chromodomain Y-like protein 2 isoform X2

UniProtKB/TrEMBL

A6IZF6

Conserved Domains (1) summary

cd06558
Location:106 → 302

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
XM_017601237.3 → XP_017456726.1 chromodomain Y-like protein 2 isoform X1

UniProtKB/TrEMBL

F1LT42

Related

ENSRNOP00000058951.3
XM_039097640.2 → XP_038953568.1 chromodomain Y-like protein 2 isoform X2

UniProtKB/TrEMBL

A6IZF6

Conserved Domains (1) summary

cd06558
Location:106 → 302

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...